TITLE

DOWN-REGULATION OF THE HOMEOBOX GENE Cdx2 BY AN ACIDIFIED BILE PULSE IN AN IN VITRO MODEL OF BARRETT'S OESOPHAGUS

AUTHOR(S)
Kapoor, N.; Yu, L.; Bodger, K.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA15
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The homeobox gene, Cdx2, is a key regulator of development and proliferation of intestinal epithelium, directly activating intestine specific genes and exerting anti-proliferative and pro-differentiating effects in vitro. Authors have shown that Cdx2 is neo-expressed in Barrett's metaplasia (BM) and that progression to malignancy is associated with down regulation at Cdx2.1 Authors aimed to examine the effect of microenvironmental changes seen in gastro-oesophageal reflux disease upon Cdx2 expression in a columnar cell model of BM. Acid and bile act synergistically cause down regulation of Cdx2 in a columnar cell model of BM.
ACCESSION #
13218869

 

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