Jenkins, G. J. S.; Harris, D. K.; Dook, S. H.; Griffiths, A. P.; Parry, J. M.; Baxter, J. N.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA14
Academic Journal
Barrett's oesophagus is known to be caused by chronic reflux of stomach contents. This reflux includes gastro-oesophageal reflux and duodeno-gastro-oesophageal reflux (DGOR). DGOR exposes the lower oesophagus to bile acids, which are known to be capable of inducing DNA damage and cytotoxicity. Authors postulated that bile acids may promote carcinogenesis in vivo by altering the gene expression of key cancer related genes. Authors exposed oesophageal cells in vitro to physiological levels of the bile acid deoxycholic acid. Authors employed complimentary DNA membrane arrays and real time PCR to determine which genes exhibited expression abnormalities after DCA exposure. The most prominent gene expression changes induced by DCA, were the switching on of the IκB and IL-8 genes. These are both transcriptional targets of the antiapoptotic factor NF-κB, suggesting activation of NF-κB by DCA.


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