Stewart, S. F.; Vidali, M.; Haugk, B.; Albano, E.; Burt, A.; Jones, D. E. J.; Day, C. P.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA13
Academic Journal
The reason why only a small proportion of heavy drinkers develop alcoholic liver disease (ALD) is still unclear. Recent work has suggested that inter individual variability in immune responses may partly explain susceptibility. As the degree of liver lymphocyte infiltration is variable in ALD, authors hypothesised that patients with higher infiltration scores would have higher magnitude immune responses against antigens associated with ethanol metabolism. In contrast to the allo-antigens studied, significantly higher litres of autoantibodies against cytochrome P4502E1 are present in patients with a heavy lymphocyte infiltrate on biopsy than in those without.


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