TITLE

ROLE OF ENQOTHELIN-1 IN THE MAINTENANCE OF SYSTEMIC AND PORTAL HAEMODYNAMICS IN PATIENTS WITH CIRRHOSIS: A RANDOMISED DOUBLE BLIND PLACEBO CONTROLLED HAEMODYNAMIC STUDY

AUTHOR(S)
Tripathi, D.; Therapondos, G.; Ferguson, J. W.; Webb, D. J.; Newby, D. E.; Hayes, P. C.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA13
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Endothelin (ET)-1 synthesis and receptor expression are increased in the injured liver. To date, there are no studies to examine the role of ET-1 on systemic and portal haemodynamics in patients with cirrhosis. For the first time, researchers have shown that ET-1 contributes to the maintenance of systemic vascular tone in patients with cirrhosis. In addition, the pulmonary effects of ET-A receptor blockade suggest a possible therapeutic role in the portopulmonary hypertension. The aim of the study is to assess the systemic and portal haemodynamic effects of selective ET-A and ET-B receptor antagonism in patients with cirrhosis and to elucidate the possible therapeutic value of selective endothelin receptor antagonism in portal hypertension.
ACCESSION #
13218862

 

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