TITLE

THE CONTRIBUTION OF THE BONE MARROW TO LIVER REGENERATION DEPENDS UPON ENDOGENOUS HEPATOCYTE REPLICATION POTENTIAL

AUTHOR(S)
Vig, P.; Russo, F.; Alison, M.; Wright, N.; Thomas, H.; Forbes, S.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA12
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Bone marrow cells (BMCs) can contribute to regeneration of the chronically damaged liver, but in human studies and animal models the magnitude of this axis is highly variable. In a murine model of hepatitis B, authors examined whether this pathway of regeneration is enhanced by inhibiting endogenous hepatocyte regeneration. BMCs contribute to the regeneration of the chronically damaged liver particularly under conditions where endogenous hepatocyte replication is blocked. It appears that both transdifferentiation and fusion occur in this model. Proliferation of small hepatocyte like progenitor cells, appearing at 6 months, may suggest that in the presence of refrorsine these cells compromise bone marrow cell engraftment in the mouse.
ACCESSION #
13218860

 

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