Vig, P.; Russo, F.; Alison, M.; Wright, N.; Thomas, H.; Forbes, S.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA12
Academic Journal
Bone marrow cells (BMCs) can contribute to regeneration of the chronically damaged liver, but in human studies and animal models the magnitude of this axis is highly variable. In a murine model of hepatitis B, authors examined whether this pathway of regeneration is enhanced by inhibiting endogenous hepatocyte regeneration. BMCs contribute to the regeneration of the chronically damaged liver particularly under conditions where endogenous hepatocyte replication is blocked. It appears that both transdifferentiation and fusion occur in this model. Proliferation of small hepatocyte like progenitor cells, appearing at 6 months, may suggest that in the presence of refrorsine these cells compromise bone marrow cell engraftment in the mouse.


Related Articles

  • Effect of alkaloidal fraction of Elaeocarpus ganitrus Roxb. seeds on murine in vitro immune parameters. Hule, Amolkumar Kisanrao; Juvekar, Archana Ramesh // Journal of Pharmacy Research;Aug2009, Vol. 2 Issue 8, p1261 

    The alkaloidal fraction of Elaeocarpus ganitrus seeds (EGAF) was prepared and evaluated for in vitro effects on murine cells for release of immune mediators and cell proliferation. The EGAF was tested at concentrations ranging between 6.5-832μg/ml. The release of mediators assayed from...

  • Identification of a natural mutant of HBV X protein truncated 27 amino acids at the COOH terminal and its effect on liver cell proliferation. Hang Zhang; Chang-liang Shan; Nan Li; Xuan Zhang; Xue-zhi Zhang; Fu-qin Xu; Shuai zhang; Li-yan Qiu; Li-hong Ye; Xiao-don Zhang // Acta Pharmacologica Sinica;Apr2008, Vol. 29 Issue 4, p473 

    Aim: To identify mutants of the hepatitis B virus (HBV) X (HBx) gene and investigate the effect of the natural mutant on liver cell proliferation. Methods: We identified natural mutants of the HBx gene from 188 sera and 48 tissues of Chinese patients infected with HBV by PCR, respectively. Based...

  • Hepatitis B viral core protein activates the hepatitis B viral enhancer II/pregenomic promoter through the nuclear factor ?B binding site. Kwon, Jin Ah; Rho, Hyune Mo // Biochemistry & Cell Biology;Aug2002, Vol. 80 Issue 4, p445 

    We here demonstrated that the hepatitis B viral (HBV) core protein (HBc) functions as a transcriptional activator on the pregenomic promoter of HBV. Detailed analyses on the HBV pregenomic promoter by serial deletion, mutation, and heterologous promoter system showed that the site responsible...

  • HBx Sensitizes Cells to Oxidative Stress-induced Apoptosis by Accelerating the Loss of Mcl-1 Protein via Caspase-3 Cascade. Liang Hu; Lei Chen; Guang Zhen Yang; Liang Li; Han Yong Sun; Yan Xin Chang; Qian Qian Tu; Meng Chao Wu; Hong Yang Wang // Molecular Cancer;2011, Vol. 10 Issue 1, p43 

    Background: Oxidative stress has been implicated in the pathogenesis of a wide spectrum of human diseases, including Hepatitis B virus (HBV)-related liver disease. Hepatitis B virus X protein (HBx) is a key regulator of HBV that exerts pleiotropic activity on cellular functions. Recent studies...

  • Does limited virucidal activity of biocides include duck hepatitis B virucidal action? Sauerbrei, Andreas; Schacke, Michael; Glck, Brigitte; Bust, Uwe; Rabenau, Holger F.; Wutzler, Peter // BMC Infectious Diseases;2012, Vol. 12 Issue 1, p276 

    Background: There is agreement that the infectivity assay with the duck hepatitis B virus (DHBV) is a suitable surrogate test to validate disinfectants for hepatitis B virucidal activity. However, since this test is not widely used, information is necessary whether disinfectants with limited...

  • Significance of the Balance between Regulatory T (Treg) and T Helper 17 (Th17) Cells during Hepatitis B Virus Related Liver Fibrosis. Jing Li; Shuang-Jian Qiu; Wei-Min She; Fu-Ping Wang; Hong Gao; Lei Li; Chuan-Tao Tu; Ji-Yao Wang; Xi-Zhong Shen; Wei Jiang // PLoS ONE;Jun2012, Vol. 7 Issue 6, p1 

    Background: Hepatitis B virus-related liver fibrosis (HBV-LF) always progresses from inflammation to fibrosis. However, the relationship between these two pathological conditions is not fully understood. Here, it is postulated that the balance between regulatory T (Treg) cells and T helper 17...

  • Organogenesis and Regeneration of Liver: Mechanism and Signal Cascade. Chattopadhyay, P.; Wahi, A. K.; Agrawal, S. S. // Asian Journal of Biochemistry;2007, Vol. 2 Issue 6, p364 

    Genetic analysis, embryonic tissue explanation and in vivo chromatin studies have together identified the distinct regulatory steps that are necessary for the development of endoderm into a bud of liver tissue and subsequently into an organ. In this review, we discuss the acquisition of...

  • Influence of Prior HIV-1 Infection on the Development of Chronic Hepatitis B Infection. Gatanaga, H.; Yasuoka, A.; Kikuchi, Y.; Tachikawa, N.; Oka, S. // European Journal of Clinical Microbiology & Infectious Diseases;Mar2000, Vol. 19 Issue 3, p237 

    The article cites a study which discusses the influence of prior HIV-1 infection on the development of chronic Hepatitis B infection. Hepatitis B virus (HBV) and HIV-1 have similar routes of transmission, and infection with the viruses occurs in the same risk groups. The data suggests that an...

  • In vitro cytotoxicity of silver nanoparticles in primary rat hepatic stellate cells. XIAOJING SUN; ZHIMING WANG; SHENGYONG ZHAI; YINGWEN CHENG; JIE LIU; BINBIN LIU // Molecular Medicine Reports;2013, Vol. 8 Issue 5, p1365 

    The number of studies concerning silver nanoparticles (AgNPs) has increased, due in part to their potential uses for biomedical applications. These particles have been demonstrated in the elimination of the hepatitis B virus and the inhibition of the proliferation of various cancer cells in vivo...


Read the Article


Sign out of this library

Other Topics