TITLE

A SIGNIFICANT PROPORTION OF MYOFIBROBLASTS ARE OF BONE MARROW ORIGIN IN HUMAN LIVER FIBROSIS

AUTHOR(S)
Russo, F. P.; Burra, P.; Rugge, M.; Wright, N. A.; Alison, M. R.; Forbes, S. J.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA12
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Myofibroblasts of bone marrow origin have recently been found in a number of parenchymal organs such as the gut and kidney. Authors sought to analyse the origin of myofibroblasts within fibrotic liver in two scenarios: 8 male patients, who received liver transplants from female donors and subsequently developed liver fibrosis and a female recipient of a male bone marrow transplant who later developed hepatitis C induced cirrhosis. There is a significant contribution to liver cirrhosis in humans from extrahepatically derived myofibroblasts in liver disease of diverse aetiology.
ACCESSION #
13218859

 

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