TITLE

BREAKDOWN OF 1-CELL TOLERANCE TO THE PRIMARY BILIARY CIRRHOSIS (PBC) AUTOANTIGEN PYRUVATE DEHYDROGENASE COMPLEX IS A B-CELL DRIVEN PROCESS

AUTHOR(S)
Robe, A. J.; Palmer, J. M.; Kirby, J. A.; Jones, D. E. J.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA12
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The autoimmune liver disease primary biliary cirrhosis (PBC) is characterised by autoantibodies reactive with the pyruvate dehydrogenase complex (PDC). Observations from both human and murine settings suggest, however, that the key effecter immune response directed at the target biliary epithelial cells is T-cell, as opposed to antibody, mediated. Activated B-cells primed to bovine PDC are able to present mouse PDC-derived autoepitopes, thereby priming autoreactive T-cell responses. B-cells primed to foreign antigen but cross reactive with self drive the breakdown of T-cell tolerance to self-PDC seen in PBC.
ACCESSION #
13218858

 

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