Dhar, A.; Johnson, K. S.; Novelli, M. R.; Bown, S. G.; Lovat, L. B.; Bloom, S. L.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA9
Academic Journal
Diagnosis of colonic pathology requires conventional histology of multiple biopsies, which has a high sampling error and a low diagnostic yield. Elastic Scattering Spectroscopy (ESS) is a novel optical technique, which can distinguish between normal and abnormal tissue instantaneously in vivo. Authors present their initial results using thisnovel technology in the colon. Despite small data sets particularly for hyperplastic polyps, these data suggest that ESS may be capable of differentiating various colonic lesions in real time allowing an in vivo optical biopsy measurement. It may be valuable in targeting polypectomy and dysplasia surveillance in patients with chronic ulcerative colitis.


Related Articles

  • Is Colonoscopy Alone Sufficient to Screen for Ulcerative Colitis-associated Colorectal Carcinoma? World J. Surg. Vol. 27, No. 5, May 2003. Bruewer, Matthias; Krieglstein, Christian F.; Utech, Markus; Bode, Marc; Rijcken, Emile; Anthoni, Christoph; Laukoetter, Mike G.; Schuermann, Guido; Senninger, Norbert // World Journal of Surgery;May2003, Vol. 27 Issue 5, p611 

    Patients with ulcerative colitis (UC) are at increased risk for colorectal carcinoma (CAC). Despite the fact that patients at risk are followed closely by colonoscopy to screen for dysplasia, the prevalence of CAC is still unacceptably high. The aim of this study was to evaluate the prevalence...

  • p53 Mutations are Associated with Dysplasia and Progression of Dysplasia in Patients with Crohn’s Disease. Jeffrey Nathanson; Nicole Yadron; Jeanne Farnan; Sydney Kinnear; John Hart // Digestive Diseases & Sciences;Feb2008, Vol. 53 Issue 2, p474 

    Abstract   Background: Mutations in the tumor suppressor gene p53 are associated with neoplasia in ulcerative colitis, but little is understood of their significance in Crohn’s disease (CD). Purpose: To explore p53 expression as a marker of neoplasia in CD patients....

  • The management of dysplasia associated with ulcerative colitis: colectomy versus continued surveillance. Friedlich, Martin S.; Guindi, Maha; Stern, Hartley S. // Canadian Journal of Surgery;Jun2004, Vol. 47 Issue 3, p212 

    The article focuses on the management of dysplasia associated with ulcerative colitis (UC). Colectomy versus continued surveillance in patients with longstanding UC is a challenging decision. Several factors must be considered. Often such patients have quiescent disease, making the prospect of...

  • Pancolonic indigo carmine dye spraying for the detection of dysplasia in ulcerative colitis. Rutter, M. D.; Saunders, B. P.; Schofield, G.; Forbes, A.; Price, A. B.; Talbot, I. C. // Gut;Feb2004, Vol. 53 Issue 2, p256 

    Background and aims: Colonoscopic surveillance for cancer in longstanding extensive ulcerative colitis relies heavily on non-targeted mucosal biopsies. Chromoendoscopy can aid detection of subtle mucosal abnormalities. We hypothesised that routine pancolonic indigo carmine dye spraying would...

  • PERICHOLANGITIS IN PATIENTS WITH ULCERATIVE COLITIS, AND RISK FACTORS FOR PROGRESSION TO COLORECTAL CANCER. Levine, Douglas S. // American Journal of Gastroenterology;Aug1993, Vol. 88 Issue 8, p1151 

    Presents an introduction to the study "Pericholangitis and Sclerosing Cholangitis Are Risk Factors for Dysplasia and Cancer in Ulcerative Colitis," by G. R. D'Haens, B. A. Lashner and S. B. Hanauer, published in the August 1993 issue of the "American Journal of Gastroenterology." Information on...

  • Interobserver Variability in the Diagnosis of Ulcerative Colitis-Associated Dysplasia by Telepathology. Odze, Robert D.; Goldblum, John; Noffsinger, Amy; Alsaigh, Nada; Rybicki, Lyndo A.; Fogt, Franz // Modern Pathology;Apr2002, Vol. 15 Issue 4, p379 

    Telepathology (TP) is the practice of remote diagnostic consultation of electronically transmitted, static, digitalized images. The diagnostic efficacy of TP-based consultation services has not been widely tested. Dysplasia that arises in association with chronic ulcerative colitis (CUC) is, at...

  • RATIONALE FOR CANCER PREVENTION STRATEGIES IN HIGH-RISK ULCERATIVE COLITIS. Campbell, F. C.; Maxwell, R. J. // Surgeon (Edinburgh University Press);Apr2009, Vol. 7 Issue 2, p96 

    Colorectal cancer (CRC) is the most feared long-term complication in patients with ulcerative colitis (UC) and Crohn's colitis. Surveillance by colonoscopy and serial biopsy is conducted to identify patients most likely to benefit from potentially curative surgery. Within this paradigm, patients...

  • Occult Cancer in Localized Giant Pseudopolyposis. Kusunoki, Masato; Nishigami, Takashi; Yanagi, Hidenori; Okamoto, Tomoaki; Shoji, Yasutsugu; Sakanoue, Youichirou; Yamamura, Takehira; Utsunomiya, Joji // American Journal of Gastroenterology;Mar1992, Vol. 87 Issue 3, p379 

    Localized giant pseudopolyposis is a rare complication in patients with ulcerative colitis which progresses to a huge intramural polypoid mass. Our case described here is a 30-yr-old female with chronic ulcerative colitis who developed localized giant pseudopolyposis with unexpected infiltrating...

  • Is Surveillance Endoscopy Necessary after Colectomy in Ulcerative Colitis? Shuno, Yasutaka; Hata, Keisuke; Sunami, Eiji; Shinozaki, Masaru; Kawai, Kazushige; Kojima, Tetsu; Tsurita, Giichiro; Hiyoshi, Masaya; Tsuno, Nelson H.; Kitayama, Joji; Nagawa, Hirokazu // ISRN Gastroenterology;2011, Special section p1 

    The role of surveillance endoscopic followup in colectomized patients with long standing total colitis is controversial. Here, we aimed to clarify its usefulness for the early detection of dysplasia and cancer in this group of patients. Ninety-seven colectomised UC patients followedup by...


Read the Article


Sign out of this library

Other Topics