Hurlstone, D. P.; Cross, S. S.; Shorthouse, A. J.; Brown, S.; Adam, I.; Lobo, A. J.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA9
Academic Journal
Aberrant crypt foci (ACF) may represent pre-neoplastic lesions in the human colon. The prevalence of ACF detected using magnification chromoscopic colonoscopy is known to follow a stepwise progression from normal subjects to those with exophytic adenomas and colon cancer (CC). No studies have addressed the prevalence of rectal ACF in patients with hot and depressed colonic lesions that cluster within the right hemi-colon and may undergo de nova neoplastic transformation. Detection of ACF in the rectum may be a useful biomarker for proximal colonic flat neoplasia and could be used at index flexible sigmoidoscopic screening to stratify risk of right-hemi-colonic neoplasia. Patients with dysplastic ACF of high density should receive total colonoscopy.


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