TITLE

COELIAC DISEASE AND SMALL BOWEL ADENOCARCINOMA--AN INITIAL ANALYSIS OF THE UNDERLYING MECHANISMS

AUTHOR(S)
Maude, K. M.; Verbeke, C. S.; Quirke, P.; McMahon, M. J.; Howdle, P. D.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA8
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Coeliac disease is a chronic sensitivity to gluten, leading to characteristic small intestinal mucosal abnormalities. Malignancy is a recognised complication, although the absolute risk is very small. The mechanisms for neoplastic development are unknown. Authors aimed to explore the immunohistochemical alterations within celiac associated small bowel cancers compared to non-coeliac cases. Researchers concluded that β-Catenin expression is abnormal in the majority of celiac associated small bowel adenocarcinomas. This suggests that β-Catenin may play an important role in the development of these cancers.
ACCESSION #
13218843

 

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