Maude, K. M.; Verbeke, C. S.; Quirke, P.; McMahon, M. J.; Howdle, P. D.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA7
Academic Journal
Primary small bowel adenocarcinoma is rare. The reason for this is unknown and the mechanisms of carcinogenesis remain unclear. Authors aimed to investigate the molecular abnormalities in small bowel cancer. The p53 and APC-β-Catenin pathways play an important role in small bowel carcinogenesis. However, the low incidence of APC loss suggests that APC is not the primary molecular abnormality leading to disruption of the APC β Catenin pathway. 100 cases of primary small bowel adenocarcinoma were retrieved from the British Society of Gostroenterology National Survey, to conduct the study.


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