Leeds, J. S.; Hopper, A. D.; Edwards, S. J.; McAlindon, M. E.; Lobo, A. J.; Donnelly, M. T.; Sanders, D. S.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA7
Academic Journal
Continuing gastrointestinal (GI) symptoms in patients with coeliac disease (CD) may indicate continued gluten exposure. However, a proportion of patients with CD still have GI symptoms, particularly diarrhoea, even with strict adherence to a gluten free diet. These patients are often assessed for other associated causes. Exocrine pancreatic insufficiency can be assessed using the Fel-1 assay. This has been shown to be highly sensitive and specific particularly for moderate and severe exocrine pancreatic insufficiency. However, Fel-1 has not been evaluated in CD patients. The authors concluded that the overall prevalence of exocrine pancreatic insufficiency in CD is 18.8%. In CD patients with persistent GI symptoms Fel-1 is of value for the assessment of exocrine pancreatic insufficiency.


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