TITLE

ASSOCIATION OF MULTIDRUG RESISTANCE GENE (MDRJ) C3435T POLYMORPHISM WITH EXTENSIVE AND SEVERE ULCERATIVE COLITIS (UC)

AUTHOR(S)
Ho, G. T.; Nimmo, E.; Fennell, J.; Drummond, H.; Goddard, C.; Mowat, C.; Satsangi, J.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA4
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The multidrug resistance gene (MDR1) gene encodes a transmembrane efflux pump which is highly expressed on intestinal epithelial cells. The ulcerative colitis (UC) like phenotype in mdrla-deficient mice and the position of the gene within chromosome 7q22, together with recent genetic studies implicate this as a strong candidate gene for inflammatory bowel's disease. The MDR1 SNP C3435T at exon 26 correlates strongly with MDR1 expression and has been shown to be associated with increased susceptibility to UC. Authors tested whether this SNP is associated with UC and performed further genotype-phenotype analysis in a large well characterised Caucasian cohort. These data suggest that the MDR1 gene encodes determinants of disease susceptibility and behaviour UC.
ACCESSION #
13218828

 

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