Ho, G. T.; Nimmo, E.; Fennell, J.; Drummond, H.; Goddard, C.; Mowat, C.; Satsangi, J.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA4
Academic Journal
The multidrug resistance gene (MDR1) gene encodes a transmembrane efflux pump which is highly expressed on intestinal epithelial cells. The ulcerative colitis (UC) like phenotype in mdrla-deficient mice and the position of the gene within chromosome 7q22, together with recent genetic studies implicate this as a strong candidate gene for inflammatory bowel's disease. The MDR1 SNP C3435T at exon 26 correlates strongly with MDR1 expression and has been shown to be associated with increased susceptibility to UC. Authors tested whether this SNP is associated with UC and performed further genotype-phenotype analysis in a large well characterised Caucasian cohort. These data suggest that the MDR1 gene encodes determinants of disease susceptibility and behaviour UC.


Related Articles

  • The frequency of C3435T MDR1 gene polymorphism in Iranian patients with ulcerative colitis. Farnood, Alma; Naderi, Nosratollah; Moghaddam, Seyed Javad Mirhasani; Noorinayer, Babak; Firouzi, Farzad; Aghazadeh, Rahim; daryani, Nasser Ebrahimi; Zali, Mohammad Reza // International Journal of Colorectal Disease;Sep2007, Vol. 22 Issue 9, p999 

    The MDR1 (multidrug resistance) gene, located on chromosome 7, is in one of the inflammatory bowel disease susceptibility loci. It produces P-glycoprotein, a transmembrane efflux pump, transferring drugs and toxins from intracellular to extracellular domains. In the human gastrointestinal (GI)...

  • The Role of Genetics in Inflammatory Bowel Disease. Henckaerts, Liesbet; Figueroa, Carolina; Vermeire, Séverine; Sans, Miquel // Current Drug Targets;May2008, Vol. 9 Issue 5, p361 

    The volume of research undertaken on the genetic susceptibility of inflammatory bowel disease (IBD) has been tremendous. Genome-wide linkage studies pointed towards more than 10 chromosomal regions and fine-mapping of these regions led to the identification of a number of genes, including CARD15...

  • Evidence for STAT4 as a Common Autoimmune Gene: rs7574865 Is Associated with Colonic Crohn's Disease and Early Disease Onset. Glas, Jürgen; Seiderer, Julia; Nagy, Melinda; Fries, Christoph; Beigel, Florian; Weidinger, Maria; Pfennig, Simone; Wolfram Klein; Epplen, Jörg T.; Lohse, Peter; Folwaczny, Matthias; Göke, Burkhard; Ochsenkühn, Thomas; Diegelmann, Julia; Müller-Myhsok, Bertram; Roeske, Darina; Brand, Stephan // PLoS ONE;2010, Vol. 5 Issue 4, p1 

    Background: Recent studies demonstrated an association of STAT4 variants with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), indicating that multiple autoimmune diseases share common susceptibility genes. We therefore investigated the influence of STAT4 variants on the...

  • Factors associated with disease evolution in Greek patients with inflammatory bowel disease. Chatzicostas, Constantinos; Roussomoustakaki, Maria; Potamianos, Spiros; Paspatis, Gregorios; Mouzas, Ioannis; Romanos, John; Mavrogeni, Helen; Kouroumalis, Elias // BMC Gastroenterology;2006, Vol. 6, p21 

    Background: The majority of Crohn's disease patients with B1 phenotype at diagnosis (i.e. nonstricturing non-penetrating disease) will develop over time a stricturing or a penetrating pattern. Conflicting data exist on the rate of proximal disease extension in ulcerative colitis patients with...

  • Phenotypic and Functional Analysis of Lamina Propria Mononuclear Cells from Colonoscopic Biopsy Specimens in Patients with Ulcerative Colitis. Haruta, Jun-ichi; Kusugami, Kazuo; Kuroiwa, Atsuo; Ina, Kenji; Shinoda, Masataka; Morise, Kimitomo; Iokawa, Hitoshi; Morita, Mayumi; Ishihara, Akira; Sarai, Susumu // American Journal of Gastroenterology;Apr1992, Vol. 87 Issue 4, p448 

    Phenotypic and functional analysis was performed with lamina propria mononuclear cells (LPMCs) isolated from colonoscopic biopsies in 27 patients with ulcerative colitis (UC). The proportion of T lymphocytes displaying HLA-DR antigens, interleukin 2 (IL-2) receptor, and transferrin receptor was...

  • Primary Sclerosing Cholangitis and IBD. Cholongitas, Evangelos; Theocharidou, Eleni; Burroughs, Andrew K. // Inflammatory Bowel Disease Monitor;2012, Vol. 12 Issue 3, p110 

    The association between primary sclerosing cholangitis (PSC) and IBD is well documented, and the IBD in these cases may represent a distinct disease phenotype. Up to 90% of patients with PSC have IBD, usually ulcerative colitis (UC), while IBD is accompanied by PSC in approximately 5% of IBD...

  • Genetic Polymorphisms Associated With Inflammatory Bowel Disease Do Not Confer Risk for Primary Sclerosing Cholangitis. Karlsen, Tom H.; Hampe, Jochen; Wiencke, Kristine; Schrumpf, Erik; Thorsby, Erik; Lie, Benedicte A.; Broomé, Ulrika; Schreiber, Stefan; Boberg, Kirsten Muri // American Journal of Gastroenterology;Jan2007, Vol. 102 Issue 1, p115 

    OBJECTIVES: Approximately 80% of patients with primary sclerosing cholangitis (PSC) of Northern European origin have concurrent inflammatory bowel disease (IBD). The majority have ulcerative colitis, but there is also an association with Crohn's colitis. The pathogenetic link between PSC and IBD...

  • Alteration of GI symptoms in a cow with Johne disease by the dietary organosulfur, 2-mercaptoethanol. Click, Robert E. // Virulence;Oct2012, Vol. 3 Issue 6, p543 

    Sub-phenotypes of inflammatory bowel disease (IBD)--Crohn disease, ulcerative colitis and some cases of irritable bowel syndrome--are generally considered a consequence of gastrointestinal inflammation of unknown etiology. Conventional therapy and more recently biologic agents, all with varying...

  • Novel Anti-Glycan Antibodies Related to Inflammatory Bowel Disease Diagnosis and Phenotype. Seow, Cynthia H.; Stempak, Joanne M.; Wei Xu; Hui Lan; Griffiths, Anne M.; Greenberg, Gordon R.; Steinhart, A. Hillary; Dotan, Nir; Silverberg, Mark S. // American Journal of Gastroenterology;Jun2009, Vol. 104 Issue 6, p1426 

    OBJECTIVES:We sought to evaluate whether two novel immunoglobulin A (IgA) cell wall polysaccharide antibodies, anti-laminarin (anti-L) and anti-chitin (anti-C), aid in the diagnosis and phenotype differentiation of Crohn's disease (CD) and ulcerative colitis (UC).METHODS:A cohort of 818...


Read the Article


Sign out of this library

Other Topics