TITLE

VASCULOGENISIS IN COLITIS: BONE MARROW STEM CELLS ENGRAFT AND TRANSDIFFERENTIATE TO FORM VASCULAR CELL LINEAGES

AUTHOR(S)
Brittan, M.; Chance, V.; Hunt, T.; Jeffery, R.; Elia, G.; Poulsom, R.; Alison, M. R.; MacDonald, T. T.; Wright, N. A.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA3
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
It has been shown that transplanted bone marrow stem cells (BMSC) contribute to various cell lineages in the diseased colon including myofibroblasts, fibroblasts, smooth muscle (SM) cells, and epithelial cells. It can be shown that venules containing BMSC derived SM cells, endothelial cells, and pericytes in the inflamed mouse colon, highlighting the rote of BMSC in vasculogenesis in tissue regeneration. Lethally irradiated female mice were rescued by a bone marrow transplant (BMT) from male donors. Colitis was induced by intrarectal injection of trinitrobenzene sulfonic acid, 6 weeks post-BMT, and colons were analysed 1-14 days later. In situ hybridisation for the Y chromosome was combined with immunohistochemistry for specific antigens to identify transplanted cells and determine their phenotype.
ACCESSION #
13218826

 

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