TITLE

TOLL LIKE RECEPTORS 2 AND 4 UPREGULATED ON HUMAN LAMINA PROPRIA DENDRITIC CELLS IN INTESTINAL INFLAMMATION

AUTHOR(S)
Hart, A. L.; Al-Hassi, H. O.; Kamm, M. A.; Knight, S. C.; Stagg, A. J.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA3
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Dendritic cells (DC) are antigen presenting cells present in the intestinal tract that sample microbial products within the gut lumen and play a central role in linking innate and adaptive immunity. Recognition of microbes by DC is in part by toll like receptors (TLR). Authors assessed the expression of TLR2, which interacts with peptidoglycan and lipoteichoic acid from Gram positive bacteria, and TLR4, which is required for recognition of patients with inflammatory bowel disease and controls. There is low expression of TLR in normal intestinal DC which may contribute to the role of DC in tolerance and their ability to coexist with potentially activating commensal flora. Increased TLR expression by DC is associated with intestinal inflammation and may contribute to the altered immune response to microbial products.
ACCESSION #
13218825

 

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