Abeya, M.; Mahida, Y.; Ogunbiyi, O.; Keshav, S.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA3
Academic Journal
Crohn's disease (CD) is a chronic inflammatory gastrointestinal disorder characterised by an abnormal mucosal immune response, probably triggered by components of the intestinal bacterial flora, in genetically susceptible hosts. NOD2/CARD15 is the first susceptibility gene identified in CD and is thought to interact with bacterial muramyidipeptide intracellular. NOD2 is constitutively expressed in monocytes and in Paneth cells in the small intestine, possibly explaining why NOD2 mutations are particularly associated with CD of the small intestine. In this study, authors investigated Paneth cell morphology and gene expression in CD in relation to the NOD2 genotype. Using lysozyme, the most abundantly expressed Paneth cell protein as a marker, authors found an overall increase in Paneth cell numbers per crypt in the NOD2 mutant homozygous group compared with heterozygous and wild type patients.


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