TITLE

LOCALISATION OF EOSINOPHILS TO DIFFERENT SUBSPECIES OF NERVES IN INFLAMMATORY BOWEL DISEASE

AUTHOR(S)
Smyth, C. M.; Woods, S.; Thornton, M.; O'Grady, A.; Gleich, G. J.; Murray, F. E.; Costello, R. W.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA2
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The role of the eosinophil, which is a common inflammatory cell in inflamed gastrointestinal mucosa in inflammatory bowel disease (IBD) is uncertain. Many of the symptoms of IBD are due to neural dysregulation, including increased mucous production and dysmotilily. Authors hypothesised that an interaction between eosinophils and nerves may explain how inflammation is related to neural dysfunction in IBD. The aim of this study was to determine the interaction of eosinophils with nerves in IBD, and to define the type of nerves involved. Eosinophils localise to specific nerve subtypes in patients with active IBD. Interactions between these cells may influence both nerve and eosinophil function.
ACCESSION #
13218823

 

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