TITLE

IMMUNE CELL SYSFUNCTION IN PATIENTS WITH ULCERATIVE COLITIS (UC) AND THE INTERREALTIONSHIP WITH QUORUM SENSING MOLECULES PRODUCED BY GUT BACTERIAL FLORA

AUTHOR(S)
Chandran, P.; Boontham, P.; Cámara, M.; Robins, A.; Rowlands, B. J.; Eremin, O.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA2
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Deregulation of gut associated lymphoid tissue (GALT) is postulated to be important in the pathogenesis of ulcerative colitis (UC). Data from animals suggest that bacteria or their products may play a rote in GALT deregulation. Quorum Sensing Molecules (QSM) are bacterial products, able to sense population density and switch on virulent genes in the gut. Their role in UC has not been documented. Researchers have demonstrated for the first time the presence of QSMs in blood; colonic washouts were negative, but faecal samples positive. QSMs significantly inhibit dendritic cells in vitro. They also skew the immunological reaction towards T helper 2. These findings suggest a possible role of these molecules in UC.
ACCESSION #
13218822

 

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