TITLE

THE CLINICAL COURSE OF ULCERATIVE COLITIS AFTER ORTHOTOPIC LIVER TRANSPLANTATION FOR PRIMARY SCLEROSING CHOLANGITIS

AUTHOR(S)
Seddon, A. J.; Ho, G. T.; Therapondos, G.; Hayes, P. C.; Satsang, J.
PUB. DATE
April 2004
SOURCE
Gut;Apr2004 Supplement 3, Vol. 53, pA2
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Primary sclerosing cholangitis (PSC) is strongly associated with ulcerative colitis (UC). In patients with advanced liver disease secondary to PSC, orthotopic liver transplantation (OLT) remains the only therapeutic option. Previous reports on the course of UC are conflicting. Researchers documented the course of UC prior to and following OLT in patients with PSC/UC, in the Scottish Liver Transplant Unit between November 1992 and March 2003. Despite immunosuppression, UC in patients after OLT for PSC/UC follows a more aggressive clinical course after OLT and is associated with a high rate of neoplasia.
ACCESSION #
13218821

 

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