Muller, A. F.; Stevens, P. E.; McIntyre, A. S.; Ellison, J. H.; Logan, R. F.
April 2004
Gut;Apr2004 Supplement 3, Vol. 53, pA2
Academic Journal
The 2 year prospective study assessed the epidemiology at nephrotoxicity associated with 5-amino-salicylate (5-ASA) use in patients with inflammatory bowel disease (IBD) in Great Britain, from January 2000 to December 2002. The 1298 names in the British Society of Gastroenterology database reported new cases on a monthly basis. All 290 consultant members of the Renal Association reported cases every 6 months. Nephrotoxicity is a serious complication at 5-ASA therapy. Regular monitoring of renal function during treatment may allow earlier detection, particularly during the first year of therapy. Based on an IBD prevalence in the nation of 412/10 with 1-50% on treatment, researchers estimate that clinical nephrotoxicity occurs in about 1 in 4000 patients/year taking 5-ASA therapy.


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