Injury and repair in developing brain

Vaccarino, F. M.; Ment, L. R.
May 2004
Archives of Disease in Childhood -- Fetal & Neonatal Edition;May2004, Vol. 89 Issue 3, pF190
Academic Journal
journal article
Developmental compensatory mechanisms may promote neural and functional plasticity, and numerous experimental studies have documented the brain's ability to engage in regenerative mechanisms to potentially replace injured cells. The article reviews available evidence for recovery from injury in models for the preterm brain and offer hypotheses for targeting time dependent molecular and cellular repair mechanisms that have been recently gathered from animal studies. Preterm birth disrupts the genetically programmed pattern of brain genesis. To develop a clinically relevant model of the effect of preterm birth on developing brain, an animal model must be used that shows that the injury imposed results in neuropathological changes similar to those found in preterm infants.


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