TITLE

Oats to children with newly diagnosed coeliac disease: a randomised double blind study

AUTHOR(S)
Högberg, L.; Laurin, P.; Fälth-Magnusson, K.; Grant, C.; Grodzinsky, E.; Jansson, G.; Ascher, H.; Browaldh, L.; Hammersjö, J.-Å; Lindberg, E; Myrdal, U
PUB. DATE
May 2004
SOURCE
Gut;May2004, Vol. 53 Issue 5, p649
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Treatment of coeliac disease (CD) requires lifelong adherence to a strict gluten free diet (GFD) which hitherto has consisted of a diet free of wheat, rye, barley, and oats. Recent studies, mainly in adults, have shown that oats are non-toxic to CD patients. In children, only open studies comprising a small number of patients have been performed. Aim: To determine if children with CD tolerate oats in their GFD. Patients and methods: In this double blind multicentre study involving eight paediatric clinics, 116 children with newly diagnosed CD were randomised to one of two groups: one group was given a standard GFD (GFD-std) and one group was given a GFD with additional wheat free oat products (GFD-oats). The study period was one year. Small bowel biopsy was performed at the beginning and end of the study. Serum IgA antigliadin, antiendomysium, and antitissue transglutaminase antibodies were monitored at 0, 3, 6, and 12 months. Results: Ninety three patients completed the study. Median (range) daily oat intake in the GFD-oats group (n = 42) was 15(5-40) g at the six month control and 15(0-43) g at the end of the study. All patients were in clinical remission after the study period. The GFD-oats and GFD-std groups did not differ significantly at the end of the study regarding coeliac serology markers or small bowel mucosal architecture, including numbers of intraepithelial lymphocytes. Significantly more children in the youngest age group withdrew. Conclusions: This is the first randomised double blind study showing that the addition of moderate amounts of oats to a GFD does not prevent clinical or small bowel mucosal healing, or humoral immunological downregulation in coeliac children. This is in accordance with the findings of studies in adult coeliacs and indicates that oats, added to the otherwise GFD, can be accepted and tolerated by the majority of children with CD.
ACCESSION #
13148297

 

Related Articles

  • Unrecognised coeliac disease is Common in healthcare students. El-Hadi, S.; Tuthill, D.; Lewis, E.; Adisesh, A.; Moody, M.; Fifield, R.; Thomas, G.; Williams, P. E.; Jenkins, H. R. // Archives of Disease in Childhood;Sep2004, Vol. 89 Issue 9, p842 

    Coeliac disease is a lifelong intolerance to dietary gluten. Untreated it can result in malabsorption, vitamin deficiencies, anaemia, and osteoporosis. Although histology remains the cornerstone of diagnosis, over the past decade serological testing for coeliac disease has facilitated the...

  • the latest on gluten-free living. Smith, Melissa Diane // Better Nutrition;Jan2009, Vol. 71 Issue 1, p56 

    The article presents information on celiac disease and non-celiac gluten sensitivity. In both gluten sensitivity and celiac disease, the innate immune system reacts to gluten. People diagnosed with celiac disease are more likely to have symptoms such as constipation, acid-reflux-type conditions,...

  • Celiac Disease. Stevens, Lise M.; Glass, Richard M. // JAMA: Journal of the American Medical Association;3/20/2002, Vol. 287 Issue 11, p1484 

    Informs about celiac disease, which is a genetic digestive disorder of the small intestine manifested by interference with absorption of nutrients from food. Indication that people with celiac disease cannot tolerate the protein called gluten, which causes their immune system to react;...

  • WHAT IS IT... coeliac disease? Allison, Annette // Woman's Day (Australia Edition);12/15/2003, Vol. 55 Issue 50, p60 

    Presents information on Coeliac disease. Symptoms of the disease; Way to control the disease; Foods that contain gluten; Substitutes for gluten-rick food.

  • Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. Monsuur, Alienke J.; de Bakker, Paul I. W.; Alizadeh, Behrooz Z.; Zhernakova, Alexandra; Bevova, Marianna R.; Strengman, Eric; Franke, Lude; van't Slot, Ruben; van Belzen, Martine J.; Lavrijsen, Ineke C. M.; Diosdado, Begoña; Daly, Mark J.; Mulder, Chris J. J.; Mearin, M. Luisa; Meijer, Jos W. R.; Meijer, Gerrit A.; van Oort, Erica; Wapenaar, Martin C.; Koeleman, Bobby P. C.; Wijmenga, Cisca // Nature Genetics;Dec2005, Vol. 37 Issue 12, p1341 

    Celiac disease is probably the best-understood immune-related disorder. The disease presents in the small intestine and results from the interplay between multiple genes and gluten, the triggering environmental factor. Although HLA class II genes explain 40% of the heritable risk, non-HLA genes...

  • THE gluten-free diet for Kids. SPACHER, CARLA // Natural Solutions;Sep2013, Issue 156, p54 

    The article discusses the beneficial health aspects gluten-free diet and its products for children. Topics discussed include digestive symptoms such as anemia, bloating and chronic diarrhea by taking gluten in diet, risk of celiac disease in children due to gluten and the risk of attention...

  • The Significance of Duodenal Mucosal Atrophy in Patients With Common Variable Immunodeficiency. Biagi, Federico; Bianchi, Paola I.; Zilli, Alessandra; Marchese, Alessandra; Luinetti, Ombretta; Lougaris, Vassilios; Plebani, Alessandro; Villanacci, Vincenzo; Corazza, Gino R. // American Journal of Clinical Pathology;Aug2012, Vol. 138 Issue 2, p185 

    Gastrointestinal manifestations and villous atrophy can be seen in patients with common variable immunodeficiency (CVID). In some patients, infectious agents may be responsible, whereas in others, celiac disease (CD) may be the cause. In this study, we investigate the causes and the...

  • Lack of Serologic Evidence to Link IgA Nephropathy with Celiac Disease or Immune Reactivity to Gluten. Moeller, Sina; Canetta, Pietro A.; Taylor, Annette K.; Arguelles-Grande, Carolina; Snyder, Holly; Green, Peter H.; Kiryluk, Krzysztof; Alaedini, Armin // PLoS ONE;Apr2014, Vol. 9 Issue 4, p1 

    IgA nephropathy is the most common form of primary glomerulonephritis worldwide. Mucosal infections and food antigens, including wheat gluten, have been proposed as potential contributing environmental factors. Increased immune reactivity to gluten and/or association with celiac disease, an...

  • Vitamin D: The Sunshine Vitamin. Are you getting enough? Harris, Cheryl // GIG Newsletter;Winter2008, Vol. 31 Issue 1, p14 

    The article suggests the importance of vitamin D to people with celiac disease (CD) and gluten intolerance. It cites the various factors that play a role in determining how much vitamin D the body produces from sunlight which include skin pigmentation, age, sunscreen and geographic location. CD...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics