Hepcidin: what every gastroenterologist should know

Walker, A. P.; Parhidge, I.; Srai, S. K.; Dooley, J. S.
May 2004
Gut;May2004, Vol. 53 Issue 5, p624
Academic Journal
In health, the body content of iron is maintained within fairly narrow limits to provide sufficient iron for synthesis of ferroproteins essential for oxygen transport and catalysis yet avoid the toxic effects of excess. Early experiments provided tantalising evidence for a humoral regulatory factor. Recent studies indicate that a peptide hormone, hepcidin, may play a crucial regulatory role in normal iron homeostasis, haemochromatosis, and the anaemia of chronic disease. Hepcidin was identified not from studies of iron homeostasis but from investigation of novel antimicrobial peptides in body fluids.


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