TITLE

Fistulising Crohn's disease: MMPs gone awry

AUTHOR(S)
Schuppan, D.; Freitag, I.
PUB. DATE
May 2004
SOURCE
Gut;May2004, Vol. 53 Issue 5, p622
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Fistulae are a common complication of Crohn's disease (CD), and their most common perianal manifestation is present in 14-38% of CD patients in referral populations. Despite advances in conservative treatment, fistulae rarely heal, while surgical resection is effective but frequently does not prevent local recurrence or fistulising disease at other sites. Remodelling of the extracellular matrix (ECM) is a key event in chronic bowel inflammation, especially in CD which is characterised by both active fibrogenesis. As uncontrolled matrix metaloproteinases activity would virtually lead to dissolution of organs.
ACCESSION #
13148291

 

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