Fistulising Crohn's disease: MMPs gone awry

Schuppan, D.; Freitag, I.
May 2004
Gut;May2004, Vol. 53 Issue 5, p622
Academic Journal
Fistulae are a common complication of Crohn's disease (CD), and their most common perianal manifestation is present in 14-38% of CD patients in referral populations. Despite advances in conservative treatment, fistulae rarely heal, while surgical resection is effective but frequently does not prevent local recurrence or fistulising disease at other sites. Remodelling of the extracellular matrix (ECM) is a key event in chronic bowel inflammation, especially in CD which is characterised by both active fibrogenesis. As uncontrolled matrix metaloproteinases activity would virtually lead to dissolution of organs.


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