Probiotics in inflammatory bowel disease: is it all gut flora modulation?

Ghosh, S.; van Heel, D.; Playford, R. J.
May 2004
Gut;May2004, Vol. 53 Issue 5, p620
Academic Journal
There is considerable public, media and scientific interest in "natural" products, including probiotics, in modulating intestinal inflammation and health. Intestinal microflora are intimately involved in the generation of immunocompetent cells and tuning the balance between T helper 1 immunity during the development of the gut associated immune system. It is now generally accepted that the intestinal bacterial flora contributes significantly to the pathogenesis of inflammatory bowel disease (IBD) along with mucosal immune dysregulation and genetic susceptibility.


Related Articles

  • The Prevalence of Extraintestinal Diseases in Inflammatory Bowel Disease: A Population-Based Study. Bernstein, Charles N.; Blanchard, James F.; Rawsthome, Patricia; Yu, Nancy // American Journal of Gastroenterology;Apr2001, Vol. 96 Issue 4, p1116 

    OBJECTIVE: The aim of this study was to determine the prevalence of the major extraintestinal manifestations of inflammatory bowel disease (IBD) and their relation to disease diagnosis and gender. METHODS: We used the population-based University of Manitoba IBD Database, which includes...

  • IL23R and ATG16L1 SNPs in IBD: Alphabet Soup or Something More? Achkar, Jean-Paul // American Journal of Gastroenterology;Mar2008, Vol. 103 Issue 3, p628 

    The results of recently completed genome-wide association studies have rapidly advanced knowledge of inflammatory bowel disease (IBD) genetics. Several promising associations between IBD and gene variants have been identified with the two best replicated so far being variants in the IL23R and...

  • The skin: a mirror to the gut. Ghevariya, Vishal; Singhal, Shashideep; Anand, Sury // International Journal of Colorectal Disease;Jul2013, Vol. 28 Issue 7, p889 

    Introduction: This review discusses the diseases with involvement of both skin and gut. GI manifestations of vesicobullous disorders and systemic diseases and syndromes involving skin and gut, dermatologic manifestations of inflammatory bowel disease (IBD), polyposis syndromes, and GI...

  • The gut as an organ of immunology. Wittig, B. M.; Zeitz, M. // International Journal of Colorectal Disease;May2003, Vol. 18 Issue 3, p181 

    Background. In normal conditions human gut mucosa is infiltrated with a large number of mononuclear cells due to continuous stimulation by luminal antigens. This state of "physiological" inflammation is tightly controlled, as several mucosal cells interact to maintain an appropriate local immune...

  • Information management and informatics: need for a modern pathology service. Jones, Rick; O'Connor, John // Annals of Clinical Biochemistry;May2004, Vol. 41 Issue 3, p183 

    Requirements for information technology in pathology now extend well beyond the provision of purely analytical data. With the aim of achieving seamless integration of laboratory data into the total clinical pathway, 'informatics' - the art and science of turning data into useful information - is...

  • Utilization of Health Care Resources by Individuals with Inflammatory Bowel Disease in the United States: A Profile of Time Since Diagnosis. Longobardi, Teresa; Jacobs, Phillip; Bernstein, Charles N. // American Journal of Gastroenterology;Apr2004, Vol. 99 Issue 4, p650 

    BACKGROUND: There are no cost studies of inflammatory bowel disease (IBD) that describe its impact on resource utilization or treatment costs over long periods of time. Our aim was to determine if there are observable trends in health-care resource utilization by adults with IBD depending on...

  • REGIONAL ENTERITIS. Berger, Samuel S. // American Journal of Gastroenterology;Jul1956, Vol. 26 Issue 1, p81 

    Presents a case of a patient with regional enteritis. Persistence of abdominal pains suffered by the patient; Examination of the abdomen of the patient; Pathology of the regional enteritis.

  • The Manitoba IBD Index: Evidence for a New and Simple Indicator of IBD Activity. Clara, Ian; Lix, Lisa M.; Walker, John R.; Graff, Lesley A.; Miller, Norine; Rogala, Linda; Rawsthorne, Patricia; Bernstein, Charles N. // American Journal of Gastroenterology;Jul2009, Vol. 104 Issue 7, p1754 

    OBJECTIVES:A single-item indicator of disease activity over an extended period of time, the Manitoba Inflammatory Bowel Disease Index (MIBDI), is introduced and compared against several standard measures for assessing activity in patients with Crohn's disease (CD) and ulcerative colitis...

  • Inflammatory bowel disease posters.  // Gut;Apr2005 Supplement 2, Vol. 54, pA89 

    The article presents information on abstracts related to inflammatory bowel disease. An abstract presents information on the faecal calprotectin in the management of IBD and in the assessment of patients with LBS. Calprotectin is a neutrophil derived protein that is stable in stool. It shows...


Read the Article


Sign out of this library

Other Topics