Prenatal risk factors of wheezing at the age of four years in Tanzania

Sunyer, J.; Mendendez, C.; Ventura, P. J.; Aponte, J. J.; Schellenberg, D.; Khigwa, E.; Acosta, C.; Antó, J. M.; Alonso, P. L.
April 2001
Thorax;Apr2001, Vol. 56 Issue 4, p290
Academic Journal
Background--A study was undertaken to assess the interactions between prenatal exposures, early life infections, atopic predisposition, and allergen exposures in the development of wheezing up to the age of 4 years in a tropical region of Africa. Methods--The study subjects comprised children born at the district hospital in Ifakara, Tanzania during a 1 year period who were participating in a trial of iron supplementation and malaria chemoprophylaxis during the first year of life and followed for up to 4 years. From this group of subjects, 658 (79%) participated in the interview at is months and 528 (64%) in a second interview at 4 years. Wheezing was measured with the ISAAC questionnaire. A hospital based inpatient and outpatient surveillance system was set up to document all attendance by study children for any cause, including episodes of clinical malaria and lower respiratory tract infections. Total IgE levels and malaria parasites were measured in maternal and cord blood. Total IgE was also measured at is months of age. Indoor environmental levels of Der p I and Fel d I were determined using an enzyme linked immunosorbent assay at the same time as the interview at the age of 18 months. Results--The prevalence of wheezing at 4 years is common in Ifakara (14%, range 13-15%). The presence of malaria parasites in cord blood (odds ratio, OR = 6.84, 95% CI 1.84 to 24.0) and maternal asthma (OR = 8.47,95% CI 2.72 to 26.2) were positively associated with wheezing at the age of 4 years, and cord blood total IgE was negatively associated (OR = 0.24, 95% CI 0.07 to 0.85) (all p


Related Articles

  • How Hidden Can Malaria Be in Pregnant Women? Diagnosis by Microscopy, Placental Histology, Polymerase Chain Reaction and Detection of Histidine-Rich Protein 2 in Plasma. Mayor, Alfredo; Moro, Laura; Aguilar, Ruth; Bardají, Azucena; Cisteró, Pau; Serra-Casas, Elisa; Sigaúque, Betuel; Alonso, Pedro L.; Ordi, Jaume; Menéndez, Clara // Clinical Infectious Diseases;Jun2012, Vol. 54 Issue 11, p1561 

    Microscopy, placental histology, and histidine-rich protein 2–based plasma diagnosis fail to identify 60% of Plasmodium falciparum infections detected by quantitative polymerase chain reaction in Mozambican pregnant women. Undetected infections are associated with maternal anemia,...

  • Susceptibility to COPD: Differential Proteomic Profiling after Acute Smoking. Franciosi, Lorenza; Postma, Dirkje S.; van den Berge, Maarten; Govorukhina, Natalia; Horvatovich, Peter L.; Fusetti, Fabrizia; Poolman, Bert; Lodewijk, Monique E.; Timens, Wim; Bischoff, Rainer; ten Hacken, Nick H. T. // PLoS ONE;Jul2014, Vol. 9 Issue 7, p1 

    Cigarette smoking is the main risk factor for COPD (Chronic Obstructive Pulmonary Disease), yet only a subset of smokers develops COPD. Family members of patients with severe early-onset COPD have an increased risk to develop COPD and are therefore defined as “susceptible...

  • Local and systemic neutrophilic inflammation in patients with lung cancer and chronic obstructive pulmonary disease. Vaguliene, Neringa; Zemaitis, Marius; Lavinskiene, Simona; Miliauskas, Skaidrius; Sakalauskas, Raimundas // BMC Immunology;2013, Vol. 14 Issue 1, p1 

    Background: Recent investigations suggest that neutrophils play an important role in the immune response to lung cancer as well as chronic obstructive pulmonary disease (COPD). The aim of this study was to evaluate the amount of neutrophils and markers of their activity in lung cancer and COPD...

  • The Role of Circulating Serotonin in the Development of Chronic Obstructive Pulmonary Disease. Lau, Way K. W.; Chan-Yeung, Moira M. W.; Yip, Benjamin H. K.; Cheung, Amy H. K.; Ip, Mary S. M.; Mak, Judith C. W. // PLoS ONE;Feb2012, Vol. 7 Issue 2, p1 

    Background: Cigarette smoking is a major risk factor in the development of age-related chronic obstructive pulmonary disease (COPD). The serotonin transporter (SERT) gene polymorphism has been reported to be associated with COPD, and the degree of cigarette smoking has been shown to be a...

  • Estimation of the Total Parasite Biomass in Acute Falciparum Malaria from Plasma PfHRP2. Dondorp, Arjen M.; Desakorn, Varunee; Pongtavornpinyo, Wirichada; Sahassananda, Duangjai; Silamut, Kamolrat; Chotivanich, Kesinee; Newton, Paul N.; Pitisuttithum, Punnee; Smithyman, A. M.; White, Nicholas J.; Day, Nicholas P. J. // PLoS Medicine;Aug2005, Vol. 2 Issue 8, p788 

    Background In falciparum malaria sequestration of erythrocytes containing mature forms of Plasmodium falciparum in the microvasculature of vital organs is central to pathology, but quantitation of this hidden sequestered parasite load in vivo has not previously been possible. The peripheral...

  • Cost-effectiveness of intermittent preventive treatment of malaria in infants (IPTi) for averting anaemia in Gabon: a comparison between intention to treat and according to protocol analyses.  // Malaria Journal;2011, Vol. 10 Issue 1, p305 

    The article focuses on the study conducted by Elisa Sicuri to examine the intermittent preventive treatment of malaria in infants (IPTi) for averting anaemia in Gabon. It mentions that threshold analysis has been conducted to identify the intervention costs and protective efficacy of IPTi for...

  • Hepatitis C Experience at a Community Teaching Hospital. Woodall, Dale W.; Godenick, Mark; Valainis, Gregory T. // Journal of Family Practice;Sep1994, Vol. 39 Issue 3, p257 

    Background. The purpose of this study was to review the initial serologic testing experience for hepatitis C (HCV) and physician response at a community teaching hospital. Methods. A retrospective chart review was performed for the 59 (5%) HCV-positive patients of 1244 patients who were tested...

  • Serum adiponectin levels and lifestyle factors in Japanese men. Kotani, Kazuhiko; Sakane, Naoki; Saiga, Kyoko; Kato, Masahiko; Ishida, Katsunori; Kato, Yosuke; Kurozawa, Youichi // Heart & Vessels;Sep2007, Vol. 22 Issue 5, p291 

    Adiponectin plays an important role in the development of various lifestyle-related diseases such as obesity, hypertension, type II diabetes mellitus, hyperlipidemia, and metabolic syndrome, leading to the development of heart and vascular diseases. However, the determinants that affect...

  • Corgenix Announces Manufacturing, Supply Agreement with diaDexus.  // Biomedical Market Newsletter;6/25/2012, Vol. 21, p1 

    The article provides information on the contract manufacturing and supply agreement between Corgenix Medical Corp. subsidiary Corgenix Inc. and diaDexus Inc. It informs that Corgenix will manufacture PLAC(r) Test ELISA product for diaDexus which will be used for measuring vascular-specific...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics