Donaldson, P T
April 2004
Gut;Apr2004, Vol. 53 Issue 4, p599
Academic Journal
The article focuses on the immunogenetic basis of chronic liver disease. Complex trait is where one or more genes acting alone or in concert increase or reduce the risk of that trait. Genetic variation result in difference in the risk of disease, the disease causing mutations or alleles do not by themselves confer disease, they simply increase or reduce the likelihood that a trait will be expressed in a given individual. Most diseases are heterogenous syndromes and the clinical phenotypes are often extremely variable. Using the term "trait" allows for this variation in the disease phenotype and the prospect that disease causing mutation not only determine which disease are more likely to develop but also may determine the severity of the clinical syndrome that follows.


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