TITLE

Hepatitis C virus among childbearing women in Scotland: prevalence, deprivation, and diagnosis

AUTHOR(S)
Hutchinson, S J; Goldberg, D J; King, M; Cameron, S O; Show, L E; Brown, A; Mackenzie, J; Wilson, K
PUB. DATE
April 2004
SOURCE
Gut;Apr2004, Vol. 53 Issue 4, p593
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives: (A) To examine the prevalence and demographic characteristics of hepatitis C virus (HCV) infection among childbearing women in Scotland; and (B) to determine the extent of maternal HCV infection diagnosed prior to birth. Methods: (A) Residual dried blood spot samples from routine neonatal screening, collected throughout Scotland during March-October 2000, were unlinked from identifiers and tested anonymously for HCV antibodies; and (B) electronic record linkage of Scotland's databases of births and diagnosed HCV infections was performed. Results: (A) Of 30 259 samples, 121 were enzyme linked immunosorbent assay repeat reactive and 88 of these were confirmed as anti-HCV positive in the recombinant immunoblot assay, representing a seroprevalence of 0.29-0.40%. HCV seroprevalence was high among 25-29 year olds (0.4-0.57%), in high deprivation areas (0.92-1.07%), and in Greater Glasgow (0.83-0.96%) and Grampian (0.38- I 0.62%). Adjusted relative risk for HCV infection was highest among residents in high deprivation areas of Glasgow (7.2 (95% confidence interval 2.0-25.5)). (B) Of 121 HCV infections found among women at delivery, 24% and 46% were estimated to have been diagnosed prior to pregnancy and birth, respectively. Conclusions: HCV prevalence among Scottish childbearing women is consistent with that expected from injecting drug use. Based on reported rates of mother to child transmission, 8-11 paediatric infections are expected per annum. Diagnosis in only 24% of infected women prior to pregnancy indicates the extent to which HCV goes unrecognised in the injecting community. The current HCV screening approach-to test only those with a history of injecting drug use (or other risk factors for infection) - identifies approximately a quarter of previously undetected infections among pregnant women.
ACCESSION #
13120628

 

Related Articles

  • Expression and Purification of E2/NS1 Protein of Hepatitis C Virus and Detection of Anti-E2/NS1 Antibodies in Chronic Liver Disease Patients. J. Pandya; A. Chakraborti; Y. Chawla // Journal of Biomedical Science;Mar/Apr2003, Vol. 10 Issue 2, p276 

    AbstractGlycoproteins on the surface of viral particles present the main target of neutralizing antibodies. The structural proteins of most Flaviviruses are known to elicit neutralizing antibodies and, thus, to help in both the natural resolution of the infection and the protection from...

  • Clearance of Hepatitis C Virus after Newly Acquired Infection in Injection Drug Users. Jauncey, Marianne; Micallef, Joanne M.; Gilmour, Stuart; Amin, Janaki; White, Peter A.; Rawlinson, William; Kaldor, John M.; Beek, Ingrid van; Dore, Gregory J. // Journal of Infectious Diseases;10/1/2004, Vol. 190 Issue 7, p1270 

    A retrospective cohort of injection drug users with newly acquired hepatitis C virus (HCV) infection was established to examine viral clearance. Newly acquired HCV infection was defined by anti-H CV antibody seroconversion within a 2-year interval. Stored serum samples were tested for HCV RNA,...

  • Hepatitis C Virus Proteins as Targets for Drug Development: The Role of Bioinformatics and Modelling. A. Lahm; A. Yagnik; A. Tramontano; U. Koch // Current Drug Targets;Aug2002, Vol. 3 Issue 4, p281 

    Hepatitis C virus (HCV), a member of the Flaviviridae family, has been recognised to be responsible for both parenterally transmitted and sporadic non-A and non-B hepatitis affecting 1-3% of the world population. HCV is a positive stranded RNA virus encoding a single polyprotein which contains...

  • Perinatal Transmission of Hepatitis G Virus (GB Virus Type C) and Hepatitis C Virus Infections--A Comparison. Wejstål, Rune; Månson, Ann-Sofie; Widell, Anders; Norkrans, Gunnar // Clinical Infectious Diseases;4/1/1999, Vol. 28 Issue 4, p816 

    Focuses on a study which analyzed the prevalences of hepatits G virus and hepatitis C virus viremia among mothers and their newborns and tested the mothers for antibody to hepatitis G virus. Patients and methods; Results; Discussion.

  • Home test for hepatitis C.  // WHO Drug Information;1999, Vol. 13 Issue 2, p94 

    Reports on the approval of the first over-the-counter blood collection kit to test for antibodies to hepatitis C virus (HCV) in the U.S. Provision of a telemedicine service; Education and counselling about HCV; Influence of HCV in causing liver damage.

  • The Prevalence of Hepatitis C Virus Antibodies among Hemodialysis Patients. Zeldis, Jerome B.; Depner, Thomas A.; Kuramoto, I.K.; Gish, Robert G.; Holland, Paul V. // Annals of Internal Medicine;6/15/90, Vol. 112 Issue 12, p958 

    Deals with a study which examined the prevalence of anti-hepatitis C virus (HCV) antibodies and the factors that predispose patients to have antibody to HCV. Methods; Results; Discussion.

  • hepacivirus.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1057 

    A definition of the medical term "hepacivirus," which refers to a family of flaviviruses that includes both the hepatitis C and hepatitis G viruses, is presented.

  • Serotyping and Genotyping of Hepatitis C Virus in Belgium. De Cock, L.; Vranckx, R. // Infection;Mar2003, Vol. 31 Issue 2, p92 

    Background: Given that both pathogenicity and the response to treatment are possibly associated with hepatitis C virus (HCV) serotype, it appeared sensible to establish the prevalence of the different HCV types in Belgium. Materials and Methods: The HCV serotypes were determined in 68 HCV-RNA...

  • Research highlights. K. A.; P. H.; J. W. T.; L. D. // Nature Biotechnology;Nov2007, Vol. 25 Issue 11, p1237 

    The article provides information on several medical research in the U.S. A research team describes a label-free optical approach to probe the interactions of biomolecules with zeptomolar sensitivity in as little as 35 pL. The said approach aims to eliminate the need for surface immobilization...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics