Histological categorisation of fibrotic cancer stroma in advanced rectal cancer

Ueno, H; Jones, A M; Wilkinson, K H; Kiss, J R; Talbot, I C
April 2004
Gut;Apr2004, Vol. 53 Issue 4, p581
Academic Journal
Background and aims: Based on conflicting reports regarding the role of the fibrotic stromal response in cancer development-namely, that a desmoplastic reaction can favour either the host or the tumour-it is dear that the role of the stromal response is varied. We have classified the fibrotic stroma of rectal adenocarcinoma penetrating the muscularis propria, based on histologically identified stromol components. Methods: Three categories of stroma were used: mature-when the stroma was composed of mature collagen fibres (fine and elongated fibres into multiple layers); intermediate-when keloid-like collagen was intermingled with mature fibres; and immature-consisting of a myxoid stroma in which no mature fibres were included. Results: In a data set of 862 patients, 53% of patients had mature fibrotic cancer stroma, 33% had intermediate stroma, and 15% had immature stroma. Five year survival rates decreased as follows: mature stroma (80%), intermediate stroma (55%), and immature stroma (27%). The adverse tumour phenotype, tumour cell budding (conspicuous isolated cells or small clusters of cancer cells), was observed in the cancer fronts in tumours with unfavourable fibrotic stroma (p<0.000l). Based on multivariate analysis, categorised fibrotic stroma was selected as an independent prognostic parameter (hazard ratio 1 .39; 95% confidence interval 1.17-1.64) together with tumour differentiation. By immunohistochemical examination, as maturation of the fibrotic stroma decreased, stromal T cells became significantly sparser. Furthermore, myofibroblasts were distributed extensively in immature fibrotic stroma compared with mature and intermediate fibrotic stroma. Conclusion: The morphological categorisation of fibrotic cancer stroma highlights the role of the stromal response in relation to the behaviour and host immune reactions of rectal adenocarcinoma and would be a useful tool for predicting patient prognostic outcome.


Related Articles

  • Granular cell tumor in inguinal region: A case of mistaken identity on cytology. Rao, Shalinee; Rajendiran S.; Surendran P.; Venkata Sai P. M.; Prathiba D. // Journal of Cytology;Jan-Mar2012, Vol. 29 Issue 1, p60 

    A 63-year-old male presented with sudden increase in size of a right inguinal swelling which was present for the past 10 years. Clinical diagnosis of inguinal soft tissue mass/lymph node enlargement was made and patient was investigated further for a conclusive diagnosis. Ultrasound examination...

  • Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization. Ji-Young Jang; Jong-Kuen Lee; Yoon-Kyung Jeon; Chul-Woo Kim // BMC Cancer;2013, Vol. 13 Issue 1, p1 

    Background: Tumor-associated macrophages (TAM) play an important role in tumor microenvironment. Particularly, M2 macrophages contribute to tumor progression, depending on the expression of NF-κB. Tumor-derived exosomes can modulate tumor microenvironment by transferring miRNAs to immune...

  • Effects of angiogenesis inhibitors on vascular network formation by human endothelial and melanoma cells. van der Schaft, Daisy W.J.; Seftor, Richard E.B.; Seftor, Elisabeth A.; Hess, Angela R.; Gruman, Lynn M.; Kirschmann, Dawn A.; Yokoyama, Yumi; Griffioen, Arjan W.; Hendrix, Mary J.C. // JNCI: Journal of the National Cancer Institute;10/6/2004, Vol. 96 Issue 19, p1473 

    Endothelial cells involved in vasculogenesis and angiogenesis are key targets in cancer therapy. Recent evidence suggests that tumor cells can express some genes typically expressed by endothelial cells and form extracellular matrix-rich tubular networks, phenomena known as vasculogenic mimicry....

  • ERRATUM.  // Current HIV Research;Jan2004, Vol. 2 Issue 1, p99 

    Correction to �Regulation of TAK / P-TEFb in CD4+T Lymphocytes and Macrophages� by Andrew P. Rice and Christine H. Herrmann published in Current HIV Research, October 2003, Vol. 1, No. 4, pp. 395-404. The correct figure 4 is given below. Earlier it missed some characters. The...

  • THE ROLE OF MACROPHAGE MIGRATION INHIBITORY FACTOR IN MODULATION OF INTERLEUKIN-17 EXPRESSION. Tamara, Cvjeticanin; Ivana, Stojanovic; Sandra, Lazaroski; Djordje, Miljkovic; Stanislava, Stosic-Grujicic // Macedonian Journal of Medical Sciences;2008 Supplement 1, Vol. 1, pS25 

    Interleukin-17 (IL-17) is a pro-inflammatory cytokine, produced by recently described Th17 cells which have critical role in immunity to extracellular bacteria and pathogenesis of several autoimmune disorders. IL-6 and TGF-β are crucial for the generation of Th17 cells, while the production...

  • Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells. Côte, Marjorie; Ménager, Mickaël M.; Burgess, Agathe; Mahlaoui, Nizar; Picard, Capucine; Schaffner, Catherine; Al-Manjomi, Fahad; Al-Harbi, Musa; Alangari, Abdullah; Le Deist, Françoise; Gennery, Andrew R.; Prince, Nathalie; Cariou, Astrid; Nitschke, Patrick; Blank, Ulrich; El-Ghazali, Gehad; Ménasché, Gaël; Latour, Sylvain; Fischer, Alain; de Saint Basile, Geneviève // Journal of Clinical Investigation;Dec2009, Vol. 119 Issue 12, p3765 

    Familial hemophagocytic lymphohistiocytosis (FHL) is a genetically heterogeneous autosomal recessive immune disorder characterized by the occurrence of uncontrolled activation of lymphocytes and macrophages infiltrating multiple organs. Disease-causing mutations in the perforin (PRF1; also known...

  • Inside Lab Invest.  // Laboratory Investigation (00236837);Nov2003, Vol. 83 Issue 11, p1541 

    This article presents information regarding several pathologic laboratory investigations. It reports that pathologists have quantitatively measured the phagocytic activity in the malignant cell. They found that several cultured melanoma lines and primary tumor cells are just as efficient at...

  • Inhibition of CSF-1R Supports T-Cell Mediated Melanoma Therapy. Sluijter, Marjolein; van der Sluis, Tetje C.; van der Velden, Pieter A.; Versluis, Mieke; West, Brian L.; van der Burg, Sjoerd H.; van Hall, Thorbald // PLoS ONE;Aug2014, Vol. 9 Issue 8, p1 

    Tumor associated macrophages (TAM) can promote angiogenesis, invasiveness and immunosuppression. The cytokine CSF-1 (or M-CSF) is an important factor of TAM recruitment and differentiation and several pharmacological agents targeting the CSF-1 receptor (CSF-1R) have been developed to regulate...

  • Adiponectin Deficiency Promotes Tumor Growth in Mice by Reducing Macrophage Infiltration. Yutong Sun; Lodish, Harvey F. // PLoS ONE;2010, Vol. 5 Issue 8, p1 

    Adiponectin is an adipocyte-derived plasma protein that has been implicated in regulating angiogenesis, but the role of adiponectin in regulating this process is still controversial. In this study, in order to determine whether adiponectin affects tumor growth and tumor induced vascularization,...


Read the Article


Sign out of this library

Other Topics