TITLE

Methylation patterns define two types of hyperplastic polyp associated with colorectal cancer

AUTHOR(S)
Wynter, C V A; Walsh, M D; Higuchi, T; Leggett, B A; Young, J; Jass, J R
PUB. DATE
April 2004
SOURCE
Gut;Apr2004, Vol. 53 Issue 4, p573
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aim: Hyperplastic polyps (HP) of the colorectum have traditionally been regarded as non-neoplastic lesions. Recent data implicate HP in the pathogenesis of colorectal cancers (CRC) characterised by extensive DNA methylation and microsatellite instability. The aim of this study was to identify morphological and molecular features that may characterises subtypes of HP with potential for neoplastic progression. Materials and methods: HP (22) clustering around distal CRC (group 1) were compared with HP (58) in subjects with hyperplastic polyposis (group II), DNA methylation was tested in methylated in tumour (MINT) loci (1, 2, 12, 31) and genes HPP1, MGMT, p14ARF, p16INK4a, and hMLHI. Results: Group II HP showed significantly more methylation than group I HP at all loci except MINTI and MGMT. Group II HP (termed HP variant) had the morphological features of the recently described "sessile serrated adenomas". Methylation of hMLHI was found most frequently in group II polyps that included foci of dysplasia (7/10) and in no group 1 lesions. Conclusion: The findings support the existence of morphological and molecular heterogeneity among HP and highlight a subset that is likely to have significant malignant potential.
ACCESSION #
13120625

 

Related Articles

  • Incidence and recurrence rates of colorectal adenomas estimated by annually repeated colonoscopies on asymptomatic Japanese. Yomaji, Y; Mitsushima, T; Ikumo, H; Watobe, H; Okamoto, M; Kowabe, T; Wada, R; Doi, H // Gut;Apr2004, Vol. 53 Issue 4, p568 

    Background: Whereas high recurrence rates of colorectal adenomas after polypectomy are widely recognised, little is known of the natural incidence in those with no neoplastic lesions initially. It is also known that single colonoscopy has a significant miss rate. Aims: To elucidate the incidence...

  • Primary hepatic non-Hodgkin's lymphomas: case report and review of the literature. Santos, Edgardo S.; Raez, Luis E.; Saivatierra, Jorge; Morgensztern, Daniel; Shanmugan, Nirmala; Neff, Guy W. // American Journal of Gastroenterology;Dec2003, Vol. 98 Issue 12, p2789 

    OBJECTIVE: The use of colonoscopy as a primary screening test for colorectal cancer (CRC) in average risk adults is a subject of controversy. Our primary objective was to build a predictive model based on a few simple variables that could be used as a guide for identifying average risk adults...

  • Are proximal colorectal cancers always associated with distal adenomas? Watson, A.J.M. // Gut;Mar2003, Vol. 52 Issue 3, p317 

    Suggests that only half of proximal colon cancers are associated with adenomas in the distal colon. Crucial assumption for the use of flexible sigmoidoscopy; Implications for the selection of the initial investigation for colorectal cancer screening.

  • Serrated lesions in colorectal cancer screening: detection, resection, pathology and surveillance. East, James E.; Vieth, Michael; Rex, Douglas K. // Gut;Jun2015, Vol. 64 Issue 6, p991 

    The article offers information on serrated lesions in colorectal cancer screening. Topics discussed include interruption of the adenoma-carcinoma sequence by endoscopic polypectomy in preventing the development of colorectal cancer, use of colonoscopy for detecting adenoma, and clinical aspects...

  • Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas. Lambert, S.; Jones, S.; Williams, G. T.; Best, J. M.; Sampson, J. R.; Cheadle, J. P. // British Journal of Cancer;4/19/2004, Vol. 90 Issue 8, p1591 

    Colorectal tumours from MYH polyposis patients display an excess of somatic G?:?C ? T?:?A transversions in the adenomatous polyposis coli gene. Here, we identify k-ras mutations in nine out of 54 (16.7%) MYH polyposis tumours. Their presence was associated with increased dysplasia and...

  • Serum CD26 is related to histopathological polyp traits and behaves as a marker for colorectal cancer and advanced adenomas. De Chiara, Loretta; Rodríguez-Piñeiro, Ana M.; Rodríguez-Berrocal, Francisco J.; Cordero, Oscar J.; Martínez-Ares, David; de la Cadena, María Páez // BMC Cancer;2010, Vol. 10, p333 

    Background: Serum CD26 (sCD26) levels were previously found diminished in colorectal cancer (CRC) patients compared to healthy donors, suggesting its potential utility for early diagnosis. Therefore we aimed to estimate the utility of the sCD26 as a biomarker for CRC and advanced adenomas in a...

  • Colorectal Cancer Screening: Is One-Year Surveillance Sigmoidoscopy Necessary? Brint, Steven L.; DiPalma, Jack A.; Herrera, Jorge L. // American Journal of Gastroenterology;Dec1993, Vol. 88 Issue 12, p2019 

    Objectives: To assess the diagnostic yield of the 1-yr follow-up flexible sigmoidoscopy examination for the detection of colonic neoplasia in a colorectal cancer screening program. Methods: Data were prospectively collected for flexible sigmoidoscopies performed between July 1991 and July 1992...

  • Sensitivity of Immunochemical Fecal Occult Blood Test to Small Colorectal Adenomas. Morikawa, Tamiya; Kato, Jun; Yamaji, Yutaka; Wada, Ryoichi; Mitsushima, Toru; Sakaguchi, Kohsaku; Shiratori, Yasushi // American Journal of Gastroenterology;Oct2007, Vol. 102 Issue 10, p2259 

    BACKGROUND: Although the immunochemical fecal occult blood test (FOBT) is reportedly more sensitive to large adenomas or colorectal cancer (CRC) than the guaiac-based FOBT, the sensitivity of the immunochemical FOBT to small adenomas has scarcely been reported. Previous reports have indicated...

  • Editorial: Sessile Serrated Adenomas and Their Pit Patterns: We Must First See the Forest Through the Trees. Burke, Carol A; Snover, Dale C // American Journal of Gastroenterology;Mar2012, Vol. 107 Issue 3, p470 

    Serrated lesions of the colorectum include hyperplastic polyps, which are non-neoplastic, and sessile serrated adenomas (SSAs, also known as sessile serrated polyps) and traditional serrated adenomas, which are premalignant. It is believed that up to 30% of colon cancers and many...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics