Assessment of reflux symptom severity: methodological options and their attributes

Bytzer, P.
May 2004
Gut;May2004 Supplement 4, Vol. 53, piv28
Academic Journal
Despite major advances in our understanding of reflux disease, the management of this disorder still presents many challenges. Reduction of heartburn is the most readily apparent objective for the patient with reflux disease. Thus the ability to measure heartburn accurately is of fundamental importance to clinical research in reflux disease. Here, the available data on the assessment of reflux symptoms-predominantly heartburn-in clinical trials or symptomatic reflux disease are examined.


Related Articles

  • Heartburn.  // American Family Physician;11/15/2003, Vol. 68 Issue 10, p2033 

    Provides information on heartburn. Definition; Causes; Tips on stopping heartburn.

  • Symptom evaluation in reflux disease: workshop background, processes, terminology, recommendations, and discussion outputs. Dent, J.; Armstrong, D.; Delaney, B.; Moayyedi, P.; Talley, N. J.; Vakil, N. // Gut;May2004 Supplement 4, Vol. 53, piv1 

    There has been no published indepth systematic evaluation of the best approaches to symptom evaluation in gastrooesophageal reflux disease (GORD). A two day international multidisciplinary workshop was therefore held in Marrakech, Morocco, in September 2002 to address these issues. The aim of...

  • Lansoprazole Heals Erosive Reflux Esophagitis Resistant to Histamine H2-Receptor Antagonist Therapy. Sontag, Stephen J.; Kogut, David G.; Fleischmann, Roy; Campbell, Donald R.; Richter, Joel; Robinson, Malcolm; McFarland, Miles; Sabesin, Seymour; Lehman, Glen A.; Castell, Donald // American Journal of Gastroenterology;Mar1997, Vol. 92 Issue 3, p429 

    Purpose: We conducted a randomized, double-blind, multicenter clinical trial to determine whether lansoprazole was superior to continued therapy with histamine H2-receptor antagonist therapy in healing erosive reflux esophagitis. Methods: Investigators from nine medical centers enrolled 159...

  • Randomised controlled trial of effects of Helicobacter pylori infection and its eradication on heartburn and gastro-oesophageal reflux:Bristol helicobacter project. Harvey, Richard F.; Lane, Athene; Murray, Liam J.; Harvey, Ian M.; Donovan, Jenny L.; Nair, Prakash // BMJ: British Medical Journal (International Edition);6/12/2004, Vol. 328 Issue 7453, p1417 

    Objectives To investigate the effects of Helicobacter pylori infection and its eradication on heartburn and gastro-esophageal reflux. Design Cross sectional study, followed by a randomized placebo controlled trial. Setting Seven general practices in Bristol, England. Participants 10,537...

  • A systematic review of symptomatic outcomes used in oesophagitis drug therapy trials. Sharma, N.; Donnellan, C.; Preston, C.; Delaney, B.; Duckelt, G.; Moayyedi, P. // Gut;May2004 Supplement 4, Vol. 53, piv58 

    Symptoms are an important outcome for measurement in clinical trials into gastro-esophageal reflux disease, but the optimal approach to symptom assessment has not been formally evaluated. The authors conducted a systematic review to assess how reflux symptoms have been evaluated and how well...

  • THE EFFECT OF LIFESTYLE MEASURES ON THE SYMPTOMS OF GASTROESOPHAGEAL REFLUX DISEASE (GORD). Gordon, C.; Sattianayagam, P.; Neild, P.; Maxwell, J. D.; Kong, J. Y. // Gut;Apr2004 Supplement 3, Vol. 53, pA25 

    This article presents information on the effect of lifestyle measures on the symptoms of gastroesophageal reflux disease (GORD). In the treatment of GORD, advice on lifestyle is often given, but its effects have not been well evaluated. Reflux symptoms were significantly improved at 2 weeks in...

  • Heartburn Correlated to 24--Hour pH Monitoring and Radiographic Examination of the Esophagus. Ott, David J.; McManus, Christopher M.; Ledbetter, M. Stephen; Chen, Michael Y. M.; Gelfand, David W. // American Journal of Gastroenterology;Oct1997, Vol. 92 Issue 10, p1827 

    Objectives: Study relationship of gastroesophageal reflux disease to findings on radiographic examination of the esophagus. Methods: We correlated heartburn (HB) in 360 patients (174 women; 186 men; mean age, 53 yr) to results of pH monitoring (pHM) and radiographic examination of the esophagus....

  • The Limitations of Gastro-Jejunal (G-J) Feeding Tubes in Children: A 9-Year Pediatric Hospital Database Analysis. Fortunato, John E.; Darbari, Anil; Mitchell, Sally E.; Thompson, Richard E.; Cuffari, Carmen // American Journal of Gastroenterology;Jan2005, Vol. 100 Issue 1, p186 

    BACKGROUND: A gastro-jejunal (G-J) feeding tube is a safe and useful temporizing method of providing enteral access in children. Although G-J tubes are often used to obviate the need for a surgical jejunostomy, their long-term use is often associated with mechanical failure.AIM: To review the...

  • Heart Burn. Wajid, M. A. // Hilal;2012, Vol. 48 Issue 12, p29 

    The article offers information on heart burn. It is reported that one in 10 people experience heart burn symptoms at least once a week. Heart burn is a burning sensation from the chest area up to the throat. It is usually associated with regurgitation of gastric acid which is the major symptom...


Read the Article


Sign out of this library

Other Topics