The Use of Frozen Section and Immunohistochemistry for Sentinel Lymph Node Biopsy in Breast Cancer

Chao, Celia
May 2004
American Surgeon;May2004, Vol. 70 Issue 5, p414
Academic Journal
Intraoperative pathologic evaluation of the sentinel lymph node (SLN) may guide immediate (synchronous) completion axillary lymph node dissection (ALND) for up to two-thirds of patients with nodal disease for breast cancer. The false-negative rates average one-third of cases, and one must be aware of false-positive results as this would result in unnecessary and morbid completion ALND. Currently, the use of immunohistochemistry (IHC) is controversial. There is no question that cytokeratin staining improves the sensitivity; however, there is no evidence that any of these "positive" cells are clinically significant and warrant therapy. Prospective randomized trials will be necessary to confirm or debunk the hypothesis that "sub-micrometastatic" disease has clinical significance.


Related Articles

  • Update on the NSABP and ACOSOG Breast Cancer Sentinel Node Trials. White Jr., Richard L.; Wilke, Lee G. // American Surgeon;May2004, Vol. 70 Issue 5, p420 

    Sentinel lymph node biopsy in women with breast cancer has become routine in many surgical practices; yet basic questions regarding the procedure remain unanswered. The National Surgical Adjuvant Bowel and Breast Project (NSABP) and the American College of Surgeons Oncology Group (ACOSOG) trials...

  • Three-dimensional reconstruction of sentinel lymph nodes with metastatic breast cancer indicates three distinct patterns of tumour growth. E C Paish // Journal of Clinical Pathology;Jul2009, Vol. 62 Issue 7, p617 

    AIM: A better understanding of the biology of nodal metastatic disease is of indisputable value. Three-dimensional (3D) serial section alignment and reconstruction techniques can be used for visualisation of nodal metastasis and could provide better understanding of disease growth patterns....

  • First Three Sentinel Lymph Nodes Accurately Stage the Axilla in Breast Cancer. KIDD, SABRINA A.; KETO, JESSICA L.; HUYNH TRAN; FITZGERALD, TIMOTHY L. // American Surgeon;Mar2009, Vol. 75 Issue 3, p253 

    Sentinel lymph node (SLN) biopsy is the preferred method of assessing lymph nodes in breast cancer. Recent literature suggests increasing morbidity with increased number of SLN removed. However, controversy exists regarding the number of SLN that should be removed. A retrospective review of...

  • Axillary sentinel lymph node micrometastases with extracapsular extension: a distinct pattern of breast cancer metastasis? Cserni, G. // Journal of Clinical Pathology;Jan2008, Vol. 61 Issue 1, p115 

    Aims: To examine the frequency of extracapsular extension (ECE) of sentinel lymph node (SLN) metastases in breast cancer according to metastasis size, and to characterise ECE in micometastases. Methods: If initially negative, SLNs were examined by step-sectioning and immunohistochemistry....

  • What is the burden of axillary disease after neoadjuvant therapy in women with locally advanced breast cancer? Cox, C.; Holloway, C.M.; Shaheta, A.; Nofech-Mozes, S.; Wright, F.C. // Current Oncology;Apr2013, Vol. 20 Issue 2, p111 

    Background The burden of axillary disease in patients with locally advanced breast cancer (LABC) after neoadjuvant therapy (NAT) has not been extensively described in a large modern cohort. Here, we describe the extent of nodal metastases after NAT in patients with LABC. Methods All patients...

  • Evaluation of Immunohistochemistry and Multiple-Level Sectioning in Sentinel Lymph Nodes From Patients With Breast Cancer. Pargaonkar, Anjali S.; Beissner, Robert S.; Snyder, Samuel; Speights Jr., V. O. // Archives of Pathology & Laboratory Medicine;Jun2003, Vol. 127 Issue 6, p701 

    Context.--Previous investigations on sentinel lymphnode biopsies have demonstrated their importance in nodal staging of patients with breast cancer. However, sentinel node biopsy in breast cancer is currently a controversial procedure and continues to provoke debate. Objectives.--We designed...

  • Clinical axillary recurrence after sentinel node biopsy in breast cancer: a follow-up study of 220 patients. Sanjuàn, A.; Vidal-Sicart, S.; Zanón, G.; Pahisa, J.; Velasco, M.; Fernández, P.L.; Santamaría, G.; Farrús, B.; Muñoz, M.; Albanell, J.; Pons, F.; Vanrell, J.A. // European Journal of Nuclear Medicine & Molecular Imaging;Aug2005, Vol. 32 Issue 8, p932 

    Purpose: The aim of this study was to evaluate the frequency of false-negative (FN) sentinel node procedures in patients with breast cancer and the subsequent clinical outcome in such patients. Methods: A total of 325 breast cancer patients underwent sentinel lymph node biopsy at our institution...

  • Semi-quantitative lymph node assessment of F-FDG PET/CT in locally advanced breast cancer: correlation with biological prognostic factors. García Vicente, Ana; Soriano Castrejón, Ángel; Cruz Mora, Miguel; González Ageitos, Ana; Muñoz Sánchez, María; León Martín, Alberto; Espinosa Aunión, Ruth; Relea Calatayud, Fernanda; Muñoz Madero, Vicente; Chacón López-Muñiz, Ignacio; Cordero García, Jose; Jiménez Londoño, Germán // European Journal of Nuclear Medicine & Molecular Imaging;Jan2013, Vol. 40 Issue 1, p72 

    Purpose: The aim of this study was to analyse the correlation between dual-time-point F-2-deoxy-2-fluoro- D-glucose (FDG) uptakes in lymph nodes assessed by positron emission tomography (PET)/CT and histopathological and immunohistochemical prognostic factors. Methods: Seventy-five women with...

  • Node retrieval in axillary lymph node dissections: recommendations for minimum numbers to be confident about node negative status. Somner, J E A; Dixon, J M J; Thomas, J S J // Journal of Clinical Pathology;Aug2004, Vol. 57 Issue 8, p845 

    Aims: To determine the minimum number of lymph nodes needed in an axillary lymph node dissection (ALND) specimen to be confident that the axilla is free from metastases. Methods: The Edinburgh Breast Unit selects patients with large and high grade tumours for ALND; 609 consecutive ALNDs...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics