Adverse Reactions to Accidental Forearm Injection of Bacille Calmette-Guérin Vaccine in Schoolchildren: 12-Month Cohort Follow-up

Gross, Samuel; Kahan, Ernesto; Vesterman, Liora; Havkin, Ofra; Leventhal, Alex
May 2004
Clinical Infectious Diseases;5/15/2004, Vol. 38 Issue 10, p1495
Academic Journal
This study examined the natural history of reaction after accidental intradermal administration of bacille Calmette-Guérin (BCG) vaccine instead of purified protein derivative (PPD) in 226 schoolchildren. At 18 days after vaccination, a local reaction with a diameter of 4.5-14 mm was found in 62% of the students, and ulceration with discharge was found in 26.6%; corresponding rates at 120 days were 72.3% and 38% and at 281 days were 73% and 6%. At 345 days, 85% of the students had a dry scar measuring 5-14 mm in diameter, and none had ulceration or discharge.


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