Antibiotic Prophylaxis for Cardiac Surgery: Does the Past Predict the Future?

Zanetti, Giorgio; Platt, Richard
May 2004
Clinical Infectious Diseases;5/15/2004, Vol. 38 Issue 10, p1364
Academic Journal
The article presents the authors comments on a meta-analysis, conducted by researcher Maureen K. Bolon and others, in which they found that the risk of surgical sit infection caused by beta-lactam-resistant gram-positive organisms in patients who received prophylaxis with glycopeptides was one-half of that observed for those who received beta-lactam antibiotics. According to the authors, unfortunately, the meta-analysis does not help in choosing a threshold above which glycopeptides should be used for prophylaxis, mainly because precise data on methicillin resistance were not available in the 7 selected studies.


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