TITLE

Antibiotic Resistance in Streptococcus pneumoniae: What Does the Future Hold?

AUTHOR(S)
Nuermberger, Eric L.; Bishai, William R.
PUB. DATE
May 2004
SOURCE
Clinical Infectious Diseases;5/15/2004 Supplement, Vol. 38, pS363
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The recent emergence of strains of drug-resistant Streptococcus pneumoniae (DRSP) is a serious clinical and public health problem. Several interventions have been proposed to limit the further emergence and spread of DRSP, including campaigns for appropriate antibiotic use and the introduction of pneumococcal conjugate vaccines. Whether the current epidemic of drug resistance in S. pneumoniae is sustainable or will succumb to current efforts to limit its spread will be decided by an interaction of factors related to the pathogen (i.e., the relative fitness of the resistant strains), to the prescription of antibiotic treatment (i.e., changes in selection pressure), and to the host (i.e., the ability to slow the transmission of DRSP). Much investigation is still needed to better ascertain how maintenance of DRSP strains in the community at large is influenced by each factor and affected by current interventions that are based on these factors.
ACCESSION #
13077051

 

Related Articles

  • Changes in Antibiotic-Prescribing Practices and Carriage of Penicillin-Resistant Streptococcus pneumoniae: A Controlled Intervention Trial in Rural Alaska. Hennessy, Thomas W.; Petersen, Kenneth M.; Bruden, Dana; Parkinson, Alan J.; Hurlburt, Debby; Getty, Marilyn; Schwartz, Benjamin; Butler, Jay C. // Clinical Infectious Diseases;6/15/2002, Vol. 34 Issue 12, p1543 

    From 1998 to 2000, 13 rural Alaskan villages (population, 3326) were surveyed annually by nasopharyngeal cultures for Streptococcus pneumoniae carriage. Data regarding antibiotic use for the entire population was abstracted from clinic records. In 1999, education of medical providers and the...

  • First multiresistant pneumococcus in Britain. Paton, J.H.; Reeves, D.S. // British Medical Journal (Clinical Research Edition);10/3/1987, Vol. 295 Issue 6602, p810 

    Investigates the occurrence of the first multiresistant pneumococcus in Great Britain. Location of origin of the disease; Resistance of the disease to penicillin; Isolation of strains with multiple resistance to antibiotics.

  • Sentinel Surveillance: A Reliable Way To Track Antibiotic Resistance in Communities? Schrag, Stephanie J.; Zell, Elizabeth R.; Schuchat, Anne; Whitney, Cynthia G. // Emerging Infectious Diseases;May2002, Vol. 8 Issue 5, p496 

    Provides information on a study that evaluated how often groups of randomly selected clinical laboratories accurately estimated the prevalence of resistant pneumococci and captured trends in resistance over time. Methodologies used; Results and discussion.

  • Antimicrobial Resistance in Streptococcus Pneumoniae, Taiwan. Po-Ren Hsueh; Kwen-Tay Luh // Emerging Infectious Diseases;Dec2002, Vol. 8 Issue 12, p1487 

    Provides information on a study which discussed the trends of pneumococcal resistance in Taiwan. Information on the antibiotic-resistant pneumococcus; Disease burden and severity; Discussion of the occurrence of multi-drug resistance; Implication of antibiotic-resistance in cases of respiratory...

  • Variable recombination dynamics during the emergence, transmission and 'disarming' of a multidrug-resistant pneumococcal clone. Croucher, Nicholas J.; Hanage, William P.; Harris, Simon R.; McGee, Lesley; van der Linden, Mark; de Lencastre, Herminia; Sá-Leão, Raquel; Jae-Hoon Song; Kwan Soo Ko; Beall, Bernard; Klugman, Keith P.; Parkhill, Julian; Tomasz, Alexander; Kristinsson, Karl G.; Bentley, Stephen D. // BMC Biology;2014, Vol. 12 Issue 1, p1 

    Background Pneumococcal β-lactam resistance was first detected in Iceland in the late 1980s, and subsequently peaked at almost 25% of clinical isolates in the mid-1990s largely due to the spread of the internationally-disseminated multidrug-resistant PMEN2 (or Spain6B-2) clone of...

  • Taking on a Gram-positive organism. Morris, David // GP: General Practitioner;6/24/2002, p67 

    Investigates the features of streptoccus pneumoniae. Use of antibiotics in dealing the organism; Increase in the resistance rates of pneumococcus to penicillin; Immunogenicity of the unconjugated vaccine in children under two years old.

  • Clinical Relevance of Macrolide-Resistant Streptococcus pneumoniae for Community-Acquired Pneumonia. Lynch III, Joseph P.; Martinez, Fernando J. // Clinical Infectious Diseases;3/1/2002 Supplement 1, Vol. 34, pS27 

    Discusses the prevalence of macrolide resistance among Streptococcus pneumoniae, risk factors and mechanisms responsible for resistance, therapeutic strategies and implications for the future. Impact of antimicrobial resistance on clinical outcomes; Clinical significance of in vitro macrolide...

  • Using Hospital Antibiogram Data To Assess regional Pneumococcal Resistance to Antibiotics. Stein, Cheryl R.; Weber, David J.; Kelley, Meera // Emerging Infectious Diseases;Feb2003, Vol. 9 Issue 2, p211 

    Focuses on a study which assessed the practicability of collecting hospital antibiogram data in North Carolina for examining pneumococcal resistance to antibiotics. Methods; Results; Discussion.

  • The Emergence of Streptococcus pneumoniae Resistant to Macrolide Antimicrobial Agents: A 6-Year... Gay, Kathryn; Baughman, Wendy; Miller, Yoon; Jackson, Delois; Whitney, Cynthia G.; Schuchat, Anne; Farley, Monica M.; Tenover, Fred; Stephens, David S. // Journal of Infectious Diseases;11/1/2000, Vol. 182 Issue 5, p1417 

    Presents an assessment of the emergence of Streptococcus pneumoniae resistant to macrolide antimicrobial agents in the population of metropolitan Atlanta, Georgia, from 1994 to 1999. Testing of isolates for antimicrobial susceptibility; Investigation of presence of ribosomal methylase gene,...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics