Gene's Crucial Role in Autoimmune Disease

Liston, Adrian
April 2004
Australasian Science;Apr2004, Vol. 25 Issue 3, p20
Identifies a single gene that teaches the immune system to recognize organ-specific proteins but can also cause diseases like diabetes. Importance of dendritic cells and mast cells to the immune system; Example of an organ-specific protein; Outcome of the random creation of a T cell.


Related Articles

  • Role of dendritic cell-mediated abnormal immune response in visceral hypersensitivity. Meng Li; Lu Zhang; Bin Lu; Zhe Chen; Li Chu; Lina Meng; Yihong Fan // International Journal of Clinical & Experimental Medicine;2015, Vol. 8 Issue 8, p13243 

    The role of dendritic cells (DCs) in irritable bowel syndrome (IBS) is unclear. This study tested the hypothesis that intestinal DCs induced visceral hypersensitivity in IBS rats through mast cell (MC) activation. The IBS rat model was established by combining colorectal distension with...

  • Protein-Tyrosine Kinases and Adaptor Proteins in FceRI-Mediated Signaling in Mast Cells. Sada, Kiyonao; Yamamura, Hirohei // Current Molecular Medicine;Feb2003, Vol. 3 Issue 1, p85 

    Mast cells function as the initiator of the allergic reaction and play a role in the innate immune system. Aggregation of the high affinity IgE receptor (FceRI) on mast cells triggers degranulation with the release of chemical mediators such as histamine, production of cytokines and...

  • Linking innate and adaptive immunity. Palucka, Karolina; Banchereau, Jacques // Nature Medicine;Aug1999, Vol. 5 Issue 8, p868 

    Identification of precursor dendritic cells as the natural interferon-producing cells reveals their role in connecting two branches of the immune system (page 919).

  • Characterisation of subpopulations of myeloid cells in infantile haemangioma. Tan, Elysia M. S.; Chudakova, Daria A.; Davis, Paul F.; Brasch, Helen D.; Itinteang, Tinte; Tan, Swee T. // Journal of Clinical Pathology;Jul2015, Vol. 68 Issue 7, p571 

    Aims Cells expressing markers of mast cells, macrophages and dendritic cells have previously been demonstrated within the interstitium of infantile haemangioma (IH). This study characterised these myeloid cellular subpopulations within IH. Methods Immunohistochemical staining was performed on...

  • Innate Immune Pathways in Host Defense. Kanneganti, Thirumala-Devi; Lamkanfi, Mohamed; Amer, Amal O. // Mediators of Inflammation;2012, Vol. 2012, p1 

    An introduction is presented in which the editor discusses various articles within the issue on topics including the role innate immune cells in liver inflammation, the role of mast cells in visceral hyperalgesia and the roles of the innate immune response to traumatic brain injury.

  • Reduced Dendritic Cells Expressing CD200R1 in Children with Inflammatory Bowel Disease: Correlation with Th17 and Regulatory T Cells. Elshal, Mohamed F.; Aldahlawi, Alia M.; Saadah, Omar I.; McCoy, J. Philip // International Journal of Molecular Sciences;2015, Vol. 16 Issue 12, p28998 

    Loss of tolerance of the adaptive immune system towards indigenous flora contributes to the development of inflammatory bowel diseases (IBD). Defects in dendritic cell (DC)-mediated innate and adoptive immune responses are conceivable. The aim of this study was to investigate the expression of...

  • Plexin-B2 and Plexin-D1 in Dendritic Cells: Expression and IL-12/IL-23p40 Production. Holl, Eda K.; Roney, Kelly E.; Allen, Irving C.; Steinbach, Erin; Arthur, Janelle C.; Buntzman, Adam; Plevy, Scott; Frelinger, Jeffrey; Ting, Jenny P.-Y.; Gabriele, Lucia // PLoS ONE;Aug2012, Vol. 7 Issue 8, Special section p1 

    Plexins are a family of genes (A,B,C, and D) that are expressed in many organ systems. Plexins expressed in the immune system have been implicated in cell movement and cell-cell interaction during the course of an immune response. In this study, the expression pattern of Plexin-B2 and...

  • Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2. Kumanogoh, Atsushi; Marukawa, Satoko; Suzuki, Kazuhiro; Takegahara, Noriko; Watanabe, Chie; Ch'ng, EweSeng; Ishida, Isao; Fujimura, Harutoshi; Sakoda, Saburo; Yoshida, Kanji; Kikutani, Hitoshi // Nature;10/10/2002, Vol. 419 Issue 6907, p629 

    Semaphorins are a family of phylogenetically conserved soluble and transmembrane proteins. Although many soluble semaphorins deliver guidance cues to migrating axons during neuronal development, some members are involved in immune responses. For example, CD100 (also known as Sema4D), a class IV...

  • A new job for dendritic cells. Lebecque, Sergei // Nature Immunology;Sep2001, Vol. 2 Issue 9, p830 

    Discusses the role and functions of dendritic cells in the immune system. Expression of interleukin-two; Enhancement of T and B cell responses; Context of major histocompatibility molecules; T cell receptor-derived and costimulation-dependent signals.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics