TITLE

Characterization of Group B Streptococci Recovered from Infants with Invasive Disease in England and Wales

AUTHOR(S)
Weisner, Abbie M.; Johnson, Alan R.; Lamagni, Theresa L.; Arnold, Eve; Warner, Marina; Heath, Paul T.; Efstratiou, Androulla
PUB. DATE
May 2004
SOURCE
Clinical Infectious Diseases;5/1/2004, Vol. 38 Issue 9, p1203
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Group B streptococci (GBS) are a major cause of invasive disease in infants, with enhanced surveillance in England and Wales showing an incidence of 0.74 cases per 1000 live births and a mortality rate of 8%. Among 353 isolates obtained during enhanced surveillance, the predominant serotypes were III (48%), Ia (27%), and V (10%), and the remainder comprised Ib, II, IV, VI, and VII; 3% were not typable. Isolates from patients with early-onset disease had serotypes III (38%), Ia (32%), and V (13%), with late-onset disease having a higher incidence of type III (67%) strains. Patients infected with serotype III strains had a higher rate of meningitis, and those with type V strains had a higher mortality rate. Isolates were susceptible to penicillin and ampicillin, but 4% were resistant to erythromycin, and 91% were resistant to tetracycline. A trivalent vaccine containing capsular polysaccharides III, Ia, and V could theoretically provide coverage against 85% of the cases of GBS disease among infants in England and Wales.
ACCESSION #
13058647

 

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