Characterization of Group B Streptococci Recovered from Infants with Invasive Disease in England and Wales

Weisner, Abbie M.; Johnson, Alan R.; Lamagni, Theresa L.; Arnold, Eve; Warner, Marina; Heath, Paul T.; Efstratiou, Androulla
May 2004
Clinical Infectious Diseases;5/1/2004, Vol. 38 Issue 9, p1203
Academic Journal
Group B streptococci (GBS) are a major cause of invasive disease in infants, with enhanced surveillance in England and Wales showing an incidence of 0.74 cases per 1000 live births and a mortality rate of 8%. Among 353 isolates obtained during enhanced surveillance, the predominant serotypes were III (48%), Ia (27%), and V (10%), and the remainder comprised Ib, II, IV, VI, and VII; 3% were not typable. Isolates from patients with early-onset disease had serotypes III (38%), Ia (32%), and V (13%), with late-onset disease having a higher incidence of type III (67%) strains. Patients infected with serotype III strains had a higher rate of meningitis, and those with type V strains had a higher mortality rate. Isolates were susceptible to penicillin and ampicillin, but 4% were resistant to erythromycin, and 91% were resistant to tetracycline. A trivalent vaccine containing capsular polysaccharides III, Ia, and V could theoretically provide coverage against 85% of the cases of GBS disease among infants in England and Wales.


Related Articles

  • Molecular characterisation of invasive Streptococcus pyogenes isolates from Hungary obtained in 2004 and 2005. Krucsó, B.; Gacs, M.; Libisch, B.; Hunyadi, Zs. Vargáné; Molnár, K.; Füzi, M.; Pászti, J. // European Journal of Clinical Microbiology & Infectious Diseases;Nov2007, Vol. 26 Issue 11, p807 

    Our aim was to characterise by molecular techniques group A streptococci isolated from invasive infections in Hungary in 2004–2005. Twenty-six nonduplicate invasive GAS isolates were selected and examined. The mortality rate proved high (52.3%) for those cases ( n = 21) where data were...

  • ACUTE HEMATOGENOUS OSTEOMYELITIS IN INFANTS. Moyson, F. R.; Deleu, J.; Achten, A. // Clinical Pediatrics;Sep1963, Vol. 2 Issue 9, p498 

    Reports on the development of acute osteomyelitis in infants. Clinical features of the disease; Diagnosis of acute osteomyelitis; Use of penicillin-streptomycin-erythromycin for the treatment of the disease.

  • A triad of endocarditis, endophthalmitis, and meningitis. Kavoliūnienė, Aušra; Jonkaitienė, Regina; Urbonaitė, Laura // Central European Journal of Medicine;Dec2013, Vol. 8 Issue 6, p795 

    Streptococcus pneumoniae is an uncommon cause of infective endocarditis; it often requires prolonged antibacterial treatment and involves a high mortality rate. We report a rare case of pneumococcal endocarditis manifesting with unusual complications — meningitis and endophthalmitis....

  • Bir üniversite hastanesi laboratuvarında beyin omurilik sıvısı'nda izole edilen mikroorganizmaların üç yıllık geriye dönük analizi. Duman, Yücel; Yakupoğulları, Yusuf; Tekerekoğlu, Mehmet Sait; Güçlüer, Nilay; Otlu, Barış // Dicle Medical Journal / Dicle Tip Dergisi;2012, Vol. 39 Issue 1, p70 

    Objectives: In this study, we aimed to investigate the agents which were isolated from cerebrospinal fluid (CSF) samples in our hospital for three years, retrospectively. Materials and methods: The CSF samples, which were sent our laboratory, of the patients those had presumptive diagnosis of...

  • Bacterial Meningitis in Children: A French Prospective Study. Bingen, Edouard; Levy, Corinne; de La Rocque, France; Boucherat, Michel; Varon, Emmanuelle; Alonso, Jean Michel; Dabernat, Henri; Reinert, Philippe; Aujard, Yannick; Cohen, Robert // Clinical Infectious Diseases;10/1/2005, Vol. 41 Issue 7, p1059 

    From January 2001 through December 2003, a total of 1084 children with bacterial meningitis were enrolled in a prospective French nationwide survey. The most frequent pathogens found in children older than 28 days were Neisseria meningitis (55.3%) and Streptococcus pneumoniae (33.4%). S....

  • Erythromycin-resistant group A streptococci on the rise in schoolchildren. Nanjagowder, Velukumar T. // Journal of Family Practice;Aug2002, Vol. 51 Issue 8, p673 

    The article presents a study which documented a resistance to erythromycin in pharyngeal isolates of group A streptococci. Children between the ages of 5 and 13 years were investigated. Three twenty two were positive for group A streptococci and were sensitive to erythromycin. The presence of M...

  • Streptococcus pneumoniae'da Makrolid Direnç Mekanizmalarının AraÅŸtırılması: 2005-2008, Marmara Ãœniversitesi Hastanesi Sonuçları. Sağiroğlu, Pınar // Marmara Medical Journal;2011, Vol. 24 Issue 1, p15 

    Objective: In this study, we aimed to determine the phenotypic characteristics and genetic determinants of macrolide resistance in the clinical isolates of Streptococcus pneumoniae. Materials and Methods: In 50 erythromycin resistant S. pneumoniae isolates, 14-, 15- membered macrolides and...

  • Trends in Antimicrobial Susceptibility of Streptococcus pneumoniae in the Tohoku District of Japan: A Longitudinal Analysis from 1998 to 2007. Suzuki, Kazumasa; Nishimaki, Katsushi; Okuyama, Kaori; Katoh, Tadashi; Yasujima, Minoru; Chihara, Junichi; Suwabe, Akira; Shibata, Yoko; Takahashi, Choichiro; Takeda, Hiroaki; Ida, Shiro; Kaku, Mitsuo; Watanabe, Akira; Nukiwa, Toshihiro; Niitsuma, Kazunao; Kanemitsu, Keiji; Takayanagi, Motoaki; Ohno, Isao // Tohoku Journal of Experimental Medicine;Jan2010, Vol. 220 Issue 1, p47 

    Streptococcus pneumoniae is a common cause of respiratory tract infections (RTIs). The prevalence of Streptococcus pneumoniae strains with reduced susceptibility to antimicrobial agents has dramatically increased worldwide. Susceptibility to nine antimicrobial agents and serotypes were...

  • Macrolide Prescriptions and Erythromycin Resistance of Streptococcus pyogenes. Gagliotti, Carlo; Nobilio, Lucia; Milandri, Milena; Luisa Moro, Maria // Clinical Infectious Diseases;4/15/2006, Vol. 42 Issue 8, p1153 

    This study shows a significant association between the number of macrolide prescriptions reimbursed by the Italian National Health Service and resistance of Streptococcus pyogenes to erythromycin in children from a region in northern Italy with high prevalence of erythromycin resistance. Recent...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics