Early surgical intervention in ulcerative colitis

Kamm, M. A.
February 2004
Gut;Feb2004, Vol. 53 Issue 2, p308
Academic Journal
The article focuses on the medical treatment for both fulminant and chronic active colitis. Intravenous cyclosporin is effective in managing fulminant ulcerative colitis. Cyclosporin can be continued even if there is mild colonic dilatation, provided the patient is clinically improving. After avoiding colectomy with cyclosporin, remission should be maintained with azathioprine. To manage chronic active disease effectively, the dose of azathioprine should be increased. Surgery is justified for cancer or high grade dysplasia, imminent perforation despite maximal drug therapy and uncontrolled chronic active disease, despite maximal immunosuppressive therapy.


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