TITLE

Chemoprevention of gastric cancer by celecoxib in rats

AUTHOR(S)
Hu, P. J.; Yu, J.; Z. R.Zeng, J.; Leung, W. K.; Lin, H. L.; Tang, B. D.; Bai, A. H. C.; Sung, J. J. Y.
PUB. DATE
February 2004
SOURCE
Gut;Feb2004, Vol. 53 Issue 2, p195
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Overexpression of cyclooxygenase 2 (COX-2) is frequently detected in gastric cancer and is believed to play a crucial role in gastric carcinogenesis. Aim: We examined the chemopreventive effect of a COX-2 inhibitor in an animal model of stomach carcinogenesis. Methods: Eighty six mate Wistar rats were divided into six different treatment groups: group A, water alone (n = 5); group B, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG 100 mg/mI) (n = 16); group C, indomethacin (3 mg/kg/day) (n =16); group D, celecoxib (5 mg/kg/day) (n = 17); group E, celecoxib (10 mg/kg/day) (n = 16); and group F, celecoxib (20 mg/kg/day) (n = 16). Group B-F animals were treated with 10% sodium chloride (in the initial six weeks) and MNNG in drinking water to induce adenocarinoma in the stomach. All animals received treatment for 40 weeks, and were sacrificed after death or at 48 weeks. Gastric neoplasm was evaluated by histology. Results: The incidences of gastric cancer were 0% in group A, 75% in group 8, 68.8% in group C, 70.6% in group D, 18.8% in group E, and 31.3% in group F (p =0.002, ANOVA). Compared with MNNG controls, treatment with celecoxib 10 mg/kg/day also showed lower tumour multiplicity (0.19 (0.40) v 1.00 (0.73); p=0.004) and lower mean tumour volume (2.4 v 2805 mm³ p=0.02). Although tumours had significantly higher COX-2 expression than their adjacent normal tissues (p<0.02), there was no significant difference in COX-2 levels among tumours in the different treatment groups. The lowest tumour prostaglandin E2 level was found in the indomethacin treated group, suggesting that the chemopreventive effect of celecoxib may be mediated by a COX independent pathway. Conclusion: While treatment with indomethacin had no significant effect on tumour development, treatment with celecoxib reduced gastric cancer incidence and growth in rats.
ACCESSION #
12998639

 

Related Articles

  • Chemoprevention in Sporadic Colorectal Cancer: The Role of Salycilates, Nsaids and Coxibs. Manzano, A; Pérez-Segura, P. // Journal of Cancer Science & Therapy;2012 Supplement, Vol. 4, p1 

    Sporadic colorectal cancer (CRC) represents 75% of the total of the CRC cases diagnosed and is the second leading cause of cancer death with a a 5-year survival rate of 62%. The development of colorectal cancer is a complex process involving multiple molecular pathways, since the formation of...

  • NSAIDs and colorectal cancer prevention. Iwama, Takeo // Journal of Gastroenterology;2009 Supplement 19, Vol. 44, p72 

    This article discusses the merits and limits of nonsteroidal antiinflammatory drugs (NSAIDs), including cyclooxygenase (COX)-2 inhibitors, for colorectal cancer prevention. The suppressive effect of NSAIDs on colorectal tumors has been recognized since as early as 1981. The chemopreventive...

  • The effect of nonsteroidal anti-inflammatory drugs on tissue healing. Chen, Michael; Dragoo, Jason // Knee Surgery, Sports Traumatology, Arthroscopy;Mar2013, Vol. 21 Issue 3, p540 

    Purpose: Non-selective (NSAIDs) and selective (COX-2) nonsteroidal anti-inflammatory drugs are commonly used for their analgesic and anti-inflammatory effects. Their role after orthopaedic surgery has been infrequently described and remains controversial because of unclear effects on soft tissue...

  • Editorial [Hot Topic: Cyclooxygenase-2 Inhibitors and Cancer (Guest Editor: J.-P. Henichart)]. H�nichart, Jean-Pierre // Anti-Cancer Agents in Medicinal Chemistry;2006, Vol. 6 Issue 3, p185 

    The discovery of an inductible form (COX-2) of cyclooxygenases expressed in inflamed tissue lead to the rapid development of selective COX-2 inhibitors [1], denominated coxibs and expected to be useful in the treatment of pathologies such as arthritis without gastrointestinal toxicity compared...

  • Evaluation of chemopreventive response of two cycloxygenase-2 inhibitors, etoricoxib and diclofenac in rat colon cancer using FTIR and NMR spectroscopic techniques. Saini, M. Kaur; Sanyal, S. Nath // Nutricion Hospitalaria;jul-ago2010, Vol. 25 Issue 4, p577 

    Non steroidal anti inflammatory drugs (NSAIDs) are efficacious in chemoprevention of colorectal cancer. Therefore, the potential ability of Etoricoxib, a selective cycloxygenase-2(COX-2) inhibitor and Diclofenac, a preferential COX-2 inhibitor are considered in the chemoprevention of 1,...

  • Factors Influencing Effects of Specific COX-2 Inhibitor NSAIDs on Growth and Differentiation of Mouse Osteoblasts on Titanium Surfaces. Arpornmaeklong, Premijt; Akarawatcharangura, Butsakorn; Pripatnanont, Prisana // International Journal of Oral & Maxillofacial Implants;2008, Vol. 23 Issue 6, p1071 

    Purpose: To investigate the influence of exposure time and stages of cell growth on the effects of specific COX-2 inhibitor NSAIDs on growth and differentiation of osteoblasts on smooth titanium surfaces. Materials and Methods: The study was categorized into 5 groups: group A, 0.1 μM...

  • Pharmacokinetics of Ecofriendly Meloxicam in Healthy Goats. Mahmood, Khawaja Tahir; Ashraf, Muhammad; Amin, Fatima; Ul Haq, Ikram; Ahmad, Mansoor Ud Din // Journal of Pharmaceutical Sciences & Research;2011, Vol. 3 Issue 1, p1035 

    Diclofenac Sodium, a Non-steroidal anti-Inflammatory drug (NSAID) was banned for veterinary use in Pakistan, India and Nepal in 2005-06 due to its relay toxicity associated with catastrophic decline in the populations of vulture in South Asia. The main aim of the present research was to study...

  • Newer Arthritis Drugs Don't Offer Anti-Bleeding Protection For Everyone.  // Tufts University Health & Nutrition Letter;Feb2003, Vol. 20 Issue 12, p6 

    Presents a study that showed the risks of taking nonsteroidal anti-inflammatories such as Cox-2 inhibitors.

  • Docking studies on NSAID/COX-2 isozyme complexes using Contact Statistics analysis. Ermondi, Giuseppe; Caron, Giulia; Lawrence, Raelene; Longo, Dario // Journal of Computer-Aided Molecular Design;Nov2004, Vol. 18 Issue 11, p683 

    The selective inhibition of COX-2 isozymes should lead to a new generation of NSAIDs with significantly reduced side effects; e.g. celecoxib (Celebrex�) and rofecoxib (Vioxx�). To obtain inhibitors with higher selectivity it has become essential to gain additional insight into the...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics