TITLE

Helicobacter pylori infection modifies gastric and plasma ghrelin dynamics in Mongolian gerbils

AUTHOR(S)
Suzuki, H.; Masaoka, I.; Hosoda, H.; Ota, T.; Minegishi, Y.; Nomura, S.; Kangawa, K.; Ishii, H.
PUB. DATE
February 2004
SOURCE
Gut;Feb2004, Vol. 53 Issue 2, p187
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background and aim: Although ghrelin, a novel growth hormone releasing peptide localised mainly in the gastric fundus, is reported not only to accelerate food passage and gastrointestinal motility but also to affect appetite and weight control, regulation of gastric ghrelin secretion under the conditions of gastric Heilcobacterpylori infection is unknown. The present study was designed to investigate plasma and gastric ghrelin levels in Mongolian gerbils with H pylon colonisation of the gastric mucosa. Methods: Gerbils orally inoculated with H pylon! were examined after inoculation. To examine preproghrelin mRNA expression in the gastric mucosa, cDNA encoding the gerbil preproghretin and glyceraldehyde-3-phosphate dehydrogenase homologue was isolated and a quantitative reverse transcription-polymerase chain reaction system was established. Results: In gerbils showing H pylon colonisation (H pylon group), expression of preproghrelin mRNA and total ghrelin levels were significantly decreased 17 and 23 weeks later (p<0.01). Although the number of ghrelin immunoreactive cells decreased as the stomach weight increased, the gastric contents of total and active ghrelin in this group were the same as those in controls. Gastric myeloperoxidase activity showed a positive correlation with plasma ghrelin levels. On the other hand, at 17 weeks, plasma ghrelin levels were significantly increased in the H pylon group (p<0.05), suggesting a compensatory increase in secretion of the peptide at this time point. Conclusion: The present experimental study demonstrated that gastric and plasma ghrelin dynamics are altered in response to H pylon: infection.
ACCESSION #
12998638

 

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