TITLE

Sensitisation of gastrointestinal tract afferents

AUTHOR(S)
McMahon, S. B.
PUB. DATE
March 2004
SOURCE
Gut;Mar2004 Supplement 2, Vol. 53, pii13
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Sensory innervation of the viscera serves a number of important functions, including regulation of visceral motility and secretory activity, and transmission of visceral sensations, including pain. There are many ways in which the sensitivity of visceral sensory neurones might be modulated, and these are discussed. Altered sensory neurone responsiveness may contribute to pathophysiological states such as irritable bowel syndrome, and the mechanisms leading to sensory neurone sensitisation offer novel targets for the treatment of such disorders.
ACCESSION #
12998626

 

Related Articles

  • How many kinds of visceral afferents? Costa, M.; Brookes, S. H. J.; Zagorodnyuk, V. // Gut;Mar2004 Supplement 2, Vol. 53, pii1 

    Most afferent signals from the viscera do not give rise to conscious experience and yet they participate in the complex neural control of visceral functions. Surprisingly little information is available on the origin, morphology, and receptor functional characteristics of the nerve endings of...

  • Visceral perception: sensory transduction in visceral afferents and nutrients. Raybould, H.E. // Gut;Jul2002 Supplement 1, Vol. 51, pI11 

    The possible mechanisms that may be involved in nutrient detection in the wall of the gastrointestinal tract are reviewed. There is strong functional and electrophysiological evidence that both intrinsic and extrinsic primary afferent neurones mediate mechanoand chemosensitive responses in the...

  • What activates visceral afferents? Gruncly, D. // Gut;Mar2004 Supplement 2, Vol. 53, pii5 

    Vagal and spinal afferents represent the information superhighways that convey sensory information from the gut to the central nervous system. These afferents are sensitive to both mechanical and chemical stimuli. Vagal afferents terminate in the muscle layers and in the mucosa. Muscle afferents...

  • Summary. Costa, M.; Glise, H.; Graffner, H. // Gut;Mar2004 Supplement 2, Vol. 53, pii22 

    Neural information from the viscera to the central nervous system (CNS) plays a very important role in health and disease. Afferent neural activity from the gastrointestinal tract signals the CNS but the nature of the stimuli required to activate the visceral afferent neurones is still not well...

  • FOREWORD. Costa, M.; Glise, H.; Graffner, H. // Gut;Mar2004 Supplement 2, Vol. 53, Preceeding pii1 

    Until now, the development of effective therapies for the treatment of functional disorders such as irritable bowel syndrome has been thwarted by a general lack of knowledge about how events in the intestine are detected by visceral afferent neurones. There are considerable gaps in our knowledge...

  • Interface between the intestinal environment and the nervous system. O. Lundgren, S. B. // Gut;Mar2004 Supplement 2, Vol. 53, pii16 

    Possible mechanisms by which the intestinal contents may influence afferent nerve fibres in the lamina propria of the intestinal mucosa are discussed in this brief review. After addressing intestinal epithelial permeability, endocrine and brush cells are discussed, as well as enterocytes, as...

  • Dissolution Media Simulating Conditions in the Proximal Human Gastrointestinal Tract: An Update. Ekarat Jantratid; Niels Janssen; Christos Reppas; Jennifer Dressman // Pharmaceutical Research;Jul2008, Vol. 25 Issue 7, p1663 

    Abstract Purpose  The aim of this study was to update the compositions of biorelevant media to represent the composition and physical chemical characteristics of the gastrointestinal fluids as closely as possible while providing physical stability during dissolution runs and short-term...

  • Dissolution Media Simulating Conditions in the Proximal Human Gastrointestinal Tract: An Update. Ekarat Jantratid; Niels Janssen; Christos Reppas; Jennifer Dressman // Pharmaceutical Research;Jul2008, Vol. 25 Issue 7, p1663 

    Abstract Purpose  The aim of this study was to update the compositions of biorelevant media to represent the composition and physical chemical characteristics of the gastrointestinal fluids as closely as possible while providing physical stability during dissolution runs and short-term...

  • gastrointestinal tract:. Huber, Jeffrey T.; Gillaspy, Mary L. // Encyclopedic Dictionary of AIDS-Related Terminology;2000, p96 

    A definition of the term "gastrointestinal tract" is presented which refers to the stomach and the intestines.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics