Recent advances in understanding molecular mechanisms of primary afferent activation

Wood, J. N.
March 2004
Gut;Mar2004 Supplement 2, Vol. 53, pii9
Academic Journal
Thermal, mechanical, and chemical stimuli depolarise specialised damage sensing neurons to initiate electrical signals that may ultimately result in a sensation of pain. Over the past decade many of the receptors that transduce these signals have been identified by molecular cloning. In the absence of specific blockers, null mutant mice have proved valuable in exploring the function of these specialised receptors. As well as the mechanisms of signal transduction, the selling of thresholds for excitation and the transmission of electrical signals have also been the focus of intense interest. In vitro studies of dorsal root ganglion sensory neurons have thus facilitated rapid advances in our understanding of the biology of nociceptors. However, the specific properties of visceral afferents are poorly defined, and useful animal models of visceral pain are only now being developed. Visceral neuron receptor subtypes and the con sequences of their activation in terms of pain perception and behaviour are thus subjects that still demand a major research effort.


Related Articles

  • CHAPTER 9: The Senses. Scanlon, Valerie C.; Sanders, Tina // Essentials of Anatomy & Physiology;Jan2007, p196 

    Chapter 9 of the book "Essentials of Anatomy & Physiology" is presented. Several terminologies relating to the senses are listed. The different parts of the sensory pathway include the receptors, sensory neurons, sensory tracts and sensory areas. Several characteristics of sensations include...

  • Sensory biases produce alternation advantage found in sequential saccadic eye movement tasks. Fecteau, Jillian H.; Au, Crystal; Armstrong, Irene T.; Munoz, Douglas P. // Experimental Brain Research;Nov2004, Vol. 159 Issue 1, p84 

    In two-choice reaction time tasks, participants respond faster when the correct decision switches across consecutive trials. Thisalternation advantagehas been interpreted as the guessing strategies of participants. Because the participants expect that the correct decision will switch across...

  • What activates visceral afferents? Gruncly, D. // Gut;Mar2004 Supplement 2, Vol. 53, pii5 

    Vagal and spinal afferents represent the information superhighways that convey sensory information from the gut to the central nervous system. These afferents are sensitive to both mechanical and chemical stimuli. Vagal afferents terminate in the muscle layers and in the mucosa. Muscle afferents...

  • Electrical activity of the sensory afferent pathway in the enteric nervous system. Miftakhov, R. N.; Wingate, D. L. // Biological Cybernetics;1996, Vol. 75 Issue 6, p471 

    In this paper we develop a mathematical model for the electrical activity of the afferent pathway, formed from the coupled primary and secondary sensory neurons. The primary sensory neuron possesses the electrical properties of AH neurons and morphological characteristics of Dogiel type II...

  • Molecular cloning and functional characterization of human vesicular glutamate transporter 3. Takamori, Shigeo; Malherbe, Pari; Broger, Clemens; Jahn, Reinhard // EMBO Reports;Aug2002, Vol. 3 Issue 8, p798 

    Glutamate is the major excitatory neurotransmitter in the mammalian CNS. It is loaded into synaptic vesicles by a proton gradient-dependent uptake system and is released by exocytosis upon stimulation. Recently, two mammalian isoforms of a vesicular glutamate transporter, VGLUT1 and VGLUT2, have...

  • Identifying a primary mechanotransducer in a model sensory system. Suslak, T.; Jarman, A. P.; Armstrong, D. // Proceedings of the Physiological Society;2014, p64P 

    An abstract of the article "Identifying a primary mechanotransducer in a model sensory system" by T. Suslak, A. P. Jarman and D. Armstrong is presented.

  • Cutaneous Sensory Thresholds from Skin Overlying Masseter and Forearm in MPD Patients and Controls. DAVIDSON, R. M.; GALE, E. N. // Journal of Dental Research;May1983, Vol. 62 Issue 5, p555 

    Cutaneous sensory thresholds from skin overlying both masseters and right ventral forearm were measured in a group of 12 MPD patients and an appropriately matched group of non-patients. No significant differences were found between the two groups, nor were there significant differences between...

  • Turbocharging neurons for growth: accelerating regeneration in the adult CNS. Woolf, Clifford J. // Nature Neuroscience;Jan2001, Vol. 4 Issue 1, p7 

    Studies the role of growth-associated proteins in the regeneration of sensory neurons in the central nervous system. Growth capacity of the axons; Molecules responsible for intrinsic growth; Upregulation and overexpression of the growth-associated gene GAP-43.

  • Local and global stabilization of coordination by sensory information. Fink, Philip W.; Foo, Patrick; Jirsa, Viktor K.; Kelso, J. A. Scott // Experimental Brain Research;Sep2000, Vol. 134 Issue 1, p9 

    In studies of rhythmic coordination, where sensory information is often generated by an auditory stimulus, spatial and temporal variability are known to decrease at points in the movement cycle coincident with the stimulus, a phenomenon known as anchoring (Byblow et al. 1994). Here we...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics