Evolving concepts on the value of adenosine hyperresponsiveness in asthma and chronic obstructive pulmonary disease

Polosó, R.; Rorke, S.; Holgate, S. T.
July 2002
Thorax;Jul2002, Vol. 57 Issue 7, p649
Academic Journal
The article examines the mechanism by which adenosine mediates bronchoconstriction in asthma and chronic obstructive pulmonary disease (COPD). The evidence in favour of the hypothesis that airway response to adenosine may better discriminate the inflammatory and immunological processes in asthma and COPD is also investigated. The article also studies the possibility that adenosine responsiveness may represent a distinctive marker of disease severity and progression. Evidences suggest that adenosine bronchoprovocation testing can be put forward in differentiating allergic asthma from COPD.


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