Comparing and combining studies of bronchial responsiveness

Chinn, S.
May 2002
Thorax;May2002, Vol. 57 Issue 5, p393
Academic Journal
Background: There is no standardised protocol for the measurement of bronchial responsiveness. Results from different studies are difficult to compare and combine. Methods: Analyses are divided between those of a continuous outcome, which can be directly standardised as effect size, and those based on a binary outcome. A published method is used to convert an odds ratio to equivalent effect size. Results: The use of effect size allows comparison between studies using a continuous outcome but different protocols, provided the relevant standard deviation is reported. Effect size from a continuous out-come and that derived from an odds ratio from an equivalent analysis gave similar results. Conclusions: Systematic reviews which include both continuous effect estimates and odds ratios can include both in one meta-analysis, provided relevant standard deviations ore published for the former. Authors are encouraged to report these in all fields in which measurement protocols vary.


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