Lung function at one month of age as a risk factor for infant respiratory symptoms in a high risk population

Murray, C. S.; Pipis, S. D.; McArdle, E. C.; Lowe, I. A.; Custovic, A.; Woodcock, A.
May 2002
Thorax;May2002, Vol. 57 Issue 5, p388
Academic Journal
Background: Abnormal premorbid lung function is a risk factor for subsequent wheezing in children with one or no atopic parent. This study was undertaken to establish whether early lung function in high risk infants (both parents atopic) was a risk factor for respiratory symptoms in infancy and to examine the influence of maternal asthma, smoking, and allergen exposure during pregnancy on any association. Methods: Infants were recruited from the NAC Manchester Asthma and Allergy Study cohort at birth. Partial forced expiratory flow volume technique under sedation was carried out to determine maximal flow at FRC (V'maxFRC). Children were followed prospectively and parents completed a standard respiratory questionnaire at one year of age. Results: Sixty nine term infants (34 boys; 88% mothers non-smokers; no household pets) underwent respiratory function testing. Size adjusted V'maxFRC was significantly lower in infants who had recurrent wheeze during the first year of life (mean 1 .3 ml/s/cm, 95% Cl 0.99 to 1 .60) than in those who did not (mean 2.03 ml/s/cm, 95% Cl 1.71 to 2.36; p=0.01). V'maxFRC was also significantly lower in infants who had recurrent cough symptoms. In multivariate regression analysis, when adjusted for age at test, sex, maternal asthma, smoking and maternal mattress Der p 1 levels, a lower size adjusted V'maxFRC score remained strongly associated with wheezing (OR 0.37, 95% Cl 0.18 to 0.77, p=0.007). Maternal smoking also remained an independent risk factor (OR 29.85, 95% CI 2.46 to 362.5, p=0.008). Conclusion: Significantly diminished lung function was present in high risk infants who subsequently wheezed and coughed. This was independent of maternal exposure to mite allergen, asthma, and smoking during pregnancy.


Related Articles

  • Conception May Take a Long Time Among Women Who Smoke. Hollander, D. // Family Planning Perspectives;Jul/Aug96, Vol. 28 Issue 4, p181 

    The article informs that women who smoke cigarettes may have difficulty becoming pregnant when they wish to, and the waiting time to conception is longest among women who smoke the most. In a large, multinational European study, women who smoked more than half a pack of cigarettes daily were...

  • Tobacco exposure during pregnancy linked to later asthma development. Foster, Melissa // Infectious Diseases in Children;Apr2010, Vol. 23 Issue 4, p31 

    The article discusses a study on a link between tobacco exposure during pregnancy and asthma development in children, presented at the American Academy of Allergy, Asthma and Immunology Meeting in New Orleans, Louisiana, from February 26 to March 2, 2010.

  • Asthma link to smoking at pregnancy reinforced.  // Australian Journal of Pharmacy;Oct2011, Vol. 92 Issue 1097, p44 

    The article presents information on the impact of tobacco smoking during pregnancy which is responsible for developing childhood asthma.

  • ODNOS SPORTSKE AKTIVNOSTI I PUÅ ENJA U TRUDNOĆI. Fetih, Anja Podlesnik // Sportekspert;Dec2010, Vol. 3 Issue 2, p28 

    The aim of the study was to point out the differences between pregnant smokers and non-smokers in connection with their physical activity and to analyse the effects of smoking and physical inactivity. The analysis proved that moderate sport activity not only facilitates well-being during...

  • The Effects of Father Involvement during Pregnancy on Receipt of Prenatal Care and Maternal Smoking. Martin, Laurie T.; McNamara, Michelle J.; Milot, Alyssa S.; Halle, Tamara; Hair, Elizabeth C. // Maternal & Child Health Journal;Nov2007, Vol. 11 Issue 6, p595 

    To examine whether women whose partners are involved in their pregnancy are more likely to receive early prenatal care and reduce cigarette consumption over the course of the pregnancy. This study also examines sociodemographic predictors of father involvement during pregnancy. Data on 5,404...

  • Sexuality & pregnancy. Headley, Susan // Youth Studies Australia;Mar1998, Vol. 17 Issue 1, p62 

    Presents an abstract entitled `Results of a Qualitative Study of Smoking Among Pregnant Adolescents,' by Y. Reid, L. Roberts et al published in the `Journal of Adolescent Health.'

  • Surgeon General's Advisory on Alcohol.  // Clinical Pediatrics;Jan1982, Vol. 21 Issue 1, p16 

    Reports on Surgeon General's advisory on alcohol and pregnancy in the United States.

  • Addressing Health Inequities in Women Care. Beliz�n, Jos� M. // Current Women's Health Reviews;2008, Vol. 4 Issue 3, p142 

    The article discusses various reports published within the issue, including one which describes the effect of maternal nutrition on long term outcomes of the progeny and another which shows the long-term effect on lung integrity of the offspring of maternal nicotine exposure.

  • Pregnancy. Clymo, Philippa // Youth Studies Australia;Autumn1995, Vol. 14 Issue 1, p60 

    Presents an abstract of the article `Patterns and covariates of tobacco use in a recent sample of pregnant teenagers,' by M. Cornelius, D. Geva, et. al. originally published in the `Journal of Adolescent Health.'


Read the Article


Sign out of this library

Other Topics