Effect of cardiopulmonary bypass on leukocyte activation: changes in membrane-bound elastase on neutrophils

Tang, M.; Gu, Y. J.; Wang, W. J.; Xu, Y. P.; Chen, C. Z.
March 2004
Perfusion;Mar2004, Vol. 19 Issue 2, p93
Academic Journal
Neutrophil elastase is known to be released from the activated leukocytes as a result of cardiopulmonary bypass (CPB). However, its biological effect on organ injury is questionable because it is quickly bound by natural proteinase inhibitors (PIs). Recently, membrane-bound elastase (MBE) was found to be able to resist the PIs' process and, thus, is biologically more active. This paper studies the effect of CPB on the kinetic change of MBE and its possible link to postoperative inflammation and organ function. CPB induces increased MBE expression on neutrophils with its peak at the end of CPB. Lack of association between neutrophil MBE and clinical markers suggests that multiple systems might be involved in the post-CPB inflammatory reaction and organ dysfunction.


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