Generic isotretinoin: a new risk for unborn children
- Dimenhydrinate: Fatal intoxication in an infant: case report. // Reactions Weekly;Nov2013, Issue 1477, p15
An abstract of the article "Fatal intoxication with diphenhydramine/dimenhydrinate (Vomex A)," by H. W. Seyberth and colleagues is presented.
- Can We Ensure the Safe Use of Known Human Teratogens?: Introduction of Generic Isotretinoin in the US as an Example. Honein, Margaret A.; Moore, Cynthia A.; Erickson, J. David // Drug Safety;2004, Vol. 27 Issue 14, p1069
The prescription of known teratogenic medications requires a careful balance between allowing women access to medications that they might need and avoiding unnecessary exposure to these medications during pregnancy because of their devastating fetal effects. Isotretinoin, a potent human...
- Can We Ensure the Safe Use of Known Human Teratogens?: The iPLEDGEÃ¢â€žÂ¢ Test Case. Honein, Margaret A.; Lindstrom, Jill A.; Kweder, Sandra L. // Drug Safety;2007, Vol. 30 Issue 1, p5
Minimising the public health burden of isotretinoin-induced teratogenicity has been a challenge for 24 years, the duration of availability of isotretinoin in the US for the treatment of severe, recalcitrant nodular acne. Although the teratogenicity of this drug is well known and risk-management...
- Vaccination Targeting a Surface Sialidase of P. acnes: Implication for New Treatment of Acne Vulgaris. Nakatsuji, Teruaki; Yu-Tsueng Liu; Cheng-Po Huang; Gallo, Richard L.; Chun-Ming Huang // PLoS ONE;2008, Vol. 3 Issue 2, p1
Background: Acne vulgaris afflicts more than fifty million people in the United State and the severity of this disorder is associated with the immune response to Propionibacterium acnes (P. acnes). Systemic therapies for acne target P. acnes using antibiotics, or target the follicle with...
- The effect of diazepam on the development of Gallus embryos. Vorster, Willie; Liebenberg, Schalk W. // South African Journal of Science;Oct95, Vol. 91 Issue 10, p538
Reports on a study to evaluate the teratogenic abnormalities resulting from exposure of chick embryos in ovo to the anxiolytic drug diazepam. Effect of diazepam on animals; Findings of the study.
- Effect of first-trimester fetal exposure to fluconazole. Apgar, Barbara // American Family Physician;4/1/1997, Vol. 55 Issue 5, p1943
States that Mastroiacovo and associates prospectively compared pregnancy outcomes in two groups of women who contacted a teratogen information service. Method used in the study; Primary indication for fluconazole treatment; Author's conclusion and recommendation.
- Adhering to caution part of systemic retinoid use. Guttman, Cheryl // Dermatology Times;Nov2001 Supplement, Vol. 22 Issue 11, pS29
Focuses on the risks for serious toxicity involved in the systemic use of retinoids for acne in Loma Linda, California. Emphasis on safety issues associated with retinoid use; Indications for the use of isotretinoin and acitretin; Hazards to the use of isotretinoin on females of childbearing...
- Oral toxicity of isotretinoin, misoprostol, methotrexate, mifepristone and levonorgestrel as pregnancy category X medications in female mice. SEONG-KWAN KIM; SOO-JEONG SHIN; YOHAN YOO; NA-HYUN KIM; DONG-SOON KIM; DAN ZHANG; JIN-A PARK; HEE YI; JIN-SUK KIM; HO-CHUL SHIN // Experimental & Therapeutic Medicine;2015, Vol. 9 Issue 3, p853
Abstract. An oral toxicity study of several pregnancy category X drugs was performed in female ICR mice. The drugs were administered orally once daily for 3 days at doses of 1, 10 and 100 Âµg/kg for isotretinoin; 6.7, 67 and 670 Âµg/kg for misoprostol; 83, 830 and 8,300 Âµg/kg for...
- Data Resources for Investigating Drug Exposure during Pregnancy and Associated Outcomes: The General Practice Research Database (GPRD) as an Alternative to Pregnancy Registries. Charlton, Rachel A.; Cunnington, Marianne C.; de Vries, Corinne S.; Weil, John G. // Drug Safety;2008, Vol. 31 Issue 1, p39
Pregnancy registries are the most commonly used data resource for the post-marketing surveillance of drug teratogenicity. However, the limited sample size and potential selection bias in these registries has led us to investigate the potential of the UK General Practice Research Database (GPRD)...