Asthma biology

December 2003
Thorax;Dec2003 Supplement 3, Vol. 58, piii60
Academic Journal
Fixed airflow obstruction occurs in a minority of patients with asthma and is associated with increased morbidity and mortality. To identify potential risk factors for the development of fixed airflow obstruction, researchers have investigated the association between post bronchodilator FEV and smoking, atopy, duration of symptoms, use of inhaled corticosteroids and induced sputum eosinophil and neutrophil counts. A minority of patients with asthma have refractory disease with poorly controlled symptoms, recurrent exacerbations and/or persistent airflow obstruction despite high dose inhaled or oral corticosteroids and additional bronchodilator therapy.


Related Articles

  • Inhaled corticosteroids are first-line control for asthma. Zablocki, Elaine // Managed Healthcare Executive;Jul2009, Vol. 19 Issue 7, p19 

    The article presents a study which evaluates the effectiveness of inhaled corticosteroids in managing asthma. Result of a study shows that asthmatic patients who spend time with a healthcare professional developing a personalized self- management plan will improved medication compliance and...

  • The Respiratory Anguish of Heaves. Kitchener, Nicole // Horse-Canada.com;Jul/Aug2012, Vol. 11 Issue 4, p14 

    The article features the equine respiratory condition called heaves, also known as recurrent airway obstruction (RAO). Frequently compared with asthma in humans, heaves are said to be chronic, incurable and can be debilitating. To reduce airway inflammation, veterinarians often use two main drug...

  • Help patients quit and optimise remaining lung function.  // New Zealand Doctor;10/28/2015, p36 

    The article discusses how to help patients quit smoking and optimise remaining lung function. Obstructive lung disease (COPD) could be prevented if an individual would stop smoking, It describes tools and methods to treat COPD including bronchodilators, theophylline, oral corticosteroids and...

  • Current treatments for chronic obstructive pulmonary disease (COPD) Cope, Graham F. // British Journal of Healthcare Management;Aug2014, Vol. 20 Issue 8, p372 

    Chronic obstructive pulmonary disease (COPD) is a common and growing problem worldwide. Although frequently linked with poverty and poor living conditions, there is strong genetic basis to the disease and chronic exposure to environmental toxins and irritants, such as cigarette smoking. Inhaled...

  • Randomised, controlled trial of N-acetylcysteine for treatment of acute exacerbations of chronic obstructive pulmonary disease [ISRCTN21676344]. Black, Peter N.; Morgan-Day, Althea; McMillan, Tracey E.; Poole, Phillippa J.; Young, Robert P. // BMC Pulmonary Medicine;2004, Vol. 4, p13 

    Background: Prophylactic treatment with N-acetylcysteine (NAC) for 3 months or more is associated with a reduction in the frequency of exacerbations of chronic obstructive pulmonary disease (COPD). This raises the question of whether treatment with NAC during an acute exacerbation will hasten...

  • Children With Severe Asthma Have Worsening Lung Function in Adolescence.  // Pulmonary Reviews;Feb2011, Vol. 16 Issue 2, p7 

    The article reports that children who suffer from severe asthma are likely to develop weakened lung function by adolescence. A study published in the January 2011 issue of the "Journal of Allergy and Clinical Immunology" notes that children with severe asthma had a lower annual increase in lung...

  • Nebulized corticosteroids in the management of acute exacerbation of COPD. Gaude, G. S.; Nadagouda, S. // Lung India;Oct-Dec2010, Vol. 27 Issue 4, p230 

    Acute exacerbations in chronic onstructive pulmonary disease (COPD) are common and systemic steroids play an important role in the management of these cases along with the bronchodilators. Nebulized budesonide is being used in the acute attacks of bronchial asthma either in children or in...

  • Evaluation and Management of Severe Asthma. Gaga, Mina; Zervas, Eleftherios; Grivas, Spiros; Castro, Mario; Chanez, Pascal // Current Medicinal Chemistry;2007, Vol. 14 Issue 9, p1049 

    Severe and difficult-to-treat asthma patients have impaired health status and account for over half of the cost of the disease and probably all of its mortality. Guideline-based treatment for these refractory asthma patients includes high doses of inhaled steroids and long acting beta2-agonists...

  • Budesonide/Formoterol: A Viewpoint by Paul W. Jones. Jones, Paul W. // Drugs;2004, Vol. 64 Issue 4, p444 

    Budesonide/formoterol is a fixed-dose combination of the corticosteroid budesonide and formoterol, a long-acting J32-agonist, inhaled as a dry powder. Current guidelines for chronic obstructive pulmonary disease (COPD) recommend a long-acting p2-agonist for patients whose symptoms are not...


Read the Article


Sign out of this library

Other Topics