ExhaIed breath: can we identify inflammation?

December 2003
Thorax;Dec2003 Supplement 3, Vol. 58, piii35
Academic Journal
Airway inflammation has a central role in the development and progression of chronic obstructive pulmonary disease (COPD) and bronchiectasis. Both pro-and anti-inflammatory mediators may control the inflammaibry response in airway disease. The aim of the study was to measure inflammatory mediators 11-6 and IL- 10 in exhaled breath condensate of patients with bronchiectasis and COPD. Oxidative stress and pulmonary inflammation are important for predicting adverse outcome in chronic conditions such as asthma and COPD. Methods used to assess inflammatory factors in lung lining fluid are limited by their pro-inflammatory nature. Exhaled breath condensate is a novel, non-invasive method to assess changes in markers of pulmonary inflammation and oxidative stress. It is not known if conventional bronchodilator therapy has any adverse or beneficial effect on such markers.


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