Innate immunity and ARDS

December 2003
Thorax;Dec2003 Supplement 3, Vol. 58, piii30
Academic Journal
Pulmonary neutrophil sequestration is a critical step in the development of acute respiratory distress syndrome (ARDS). Animal studies suggest that neutrophil emigration from the pulmonary circulation to alveolar space occurs via CD11/18 adhesion molecule dependent and independent pathways. The CD49d adhesion molecule pathway has been proposed as a potential mechanism for CD11/18 independent neutrophil recruitment. Little evidence is available about the expression of these different adhesion pathways upon neutrophils in humans with ARDS. Neutrophils are recruited to the lung in patients with ARDS, and persistent alveolar neutrophilia has adverse prognostic significance. During resolution of inflammation neutrophils are removed by apoptosis.


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